NCT07433920 L-PRF Versus Sticky Bone Grafting of the Jumping Gap in AI-assisted Computer-Guided Socket Shield Immediate Implantation
| NCT ID | NCT07433920 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Kafrelsheikh University |
| Condition | Dental Implant Failed |
| Study Type | INTERVENTIONAL |
| Enrollment | 45 participants |
| Start Date | 2026-02-23 |
| Primary Completion | 2027-03-03 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 45 participants in total. It began in 2026-02-23 with a primary completion date of 2027-03-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
the rationale of the current study is to address a focused and clinically relevant gap in socket shield therapy: which biologic modality best supports healing of the shield-implant gap when SST is performed under a standardized, digitally guided workflow. The study will compare three shield-implant gap filling modalities: (i) L-PRF alone (without membrane), (ii) sticky tooth (autogenous dentin graft +i- PRF), and (iii) sticky bone (particulate graft + i- PRF) under AI-assisted, patient-specific guided implant placement based on IOS/CBCT superimposition, with CBCT follow-up at immediate, 3 months, and 6 months. The working hypothesis is that biologically active, cohesive composites (sticky tooth and sticky bone) will provide superior hard- and soft-tissue dimensional stability compared with PRF alone by improving space maintenance and early wound stability in the shield-implant gap . The null hypothesis is that there will be no statistically significant differences between the three modalities in radiographic and digitally assessed clinical outcomes over the 6-month follow-up period .
Eligibility Criteria
Inclusion Criteria: * Medically healthy patients according to the American Society of Anesthesiologists (ASA) physical status classification system; only patients belonging to ASA I and ASA II categories will be included in this study. * Age \> 18 years. * Patients presenting with one non-restorable hopeless anterior tooth due to extensive caries, cervical/root fracture, vertical or oblique root fracture, multiple failed endodontic treatments, or root resorption. * Sufficient apical/palatal bone to obtain primary implant stability. Exclusion Criteria: * Patients belonging to ASA III, ASA IV and ASA V will be excluded. * Vertical root fracture involving the labial aspect of the root planned to be retained as the facial shield. * Horizontal root fracture that is too far apically located. * Presence of acute (active) periapical infection. * Large chronic periapical lesion. * Lack of sufficient bone apical to the extraction socket to obtain primary stability. \* Ankylosed tooth positioned too apically in relation to adjacent teeth.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07433920 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 45 Years, studying Dental Implant Failed. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07433920 currently recruiting?
Yes, NCT07433920 is actively recruiting participants. Contact the research team at waled_hammed@den.kfs.edu.eg for enrollment information.
Where is the NCT07433920 trial being conducted?
This trial is being conducted at Kafr ash Shaykh, Egypt, Kafr ash Shaykh, Egypt.
Who is sponsoring the NCT07433920 clinical trial?
NCT07433920 is sponsored by Kafrelsheikh University. The trial plans to enroll 45 participants.