NCT07409493 IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols
| NCT ID | NCT07409493 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Hanoi Medical University |
| Condition | Infertility (IVF Patients) |
| Study Type | INTERVENTIONAL |
| Enrollment | 148 participants |
| Start Date | 2026-01-21 |
| Primary Completion | 2028-06 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 148 participants in total. It began in 2026-01-21 with a primary completion date of 2028-06.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to compare two ovarian stimulation protocols used in in vitro fertilization (IVF): the fixed Progestin-Primed Ovarian Stimulation (PPOS) protocol and the GnRH Antagonist protocol. The study will evaluate IVF outcomes and embryo development patterns using time-lapse embryo monitoring technology. The main questions the study aims to answer are: * Does the fixed - PPOS protocol achieve similar numbers of mature eggs, good-quality embryos, and clinical outcomes compared to the GnRH Antagonist protocol? * Are there differences in embryo development patterns (morphokinetics) between the two protocols when monitored by time-lapse imaging? * How does embryo quality (KIDScore) compare between the two protocols? Study Design: Researchers will randomly assign 148 women undergoing IVF to two groups: * PPOS group (n=74): Will receive FSH injections (oral Duphaston 20mg daily) starting from day 2-3 of the menstrual cycle * GnRH Antagonist group (n=74): Will receive FSH injections (Orgalutran 0.25mg injections) when follicles reach ≥14mm Participants will: * Undergo controlled ovarian stimulation with their assigned protocol for approximately 10-12 days * Have regular ultrasound monitoring and blood tests to track follicle development * Undergo egg retrieval procedure when follicles are mature * Have all embryos cultured in the EmbryoScope time-lapse incubator with continuous monitoring * Have embryos frozen on Day 5/6 for future transfer Study Location: Department of Assisted Reproduction and Andrology, Hanoi Obstetrics and Gynecology Hospital Study Duration: January 2026 - June 2028
Eligibility Criteria
Inclusion Criteria: * Women aged 20-45 years * Indicated for in vitro fertilization (IVF) treatment * Planned freeze-all embryo strategy * Voluntary participation in research. Exclusion Criteria: * Systemic diseases * Use of hormonal medications within 3 months prior to enrollment * Oocyte donation cycles * Unwilling or unable to participate in research
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07409493 clinical trial?
This trial is open to female participants only, aged 20 Years or older, up to 45 Years, studying Infertility (IVF Patients). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07409493 currently recruiting?
Yes, NCT07409493 is actively recruiting participants. Contact the research team at huythanhdao.hmu@gmail.com for enrollment information.
Where is the NCT07409493 trial being conducted?
This trial is being conducted at Hanoi, Vietnam.
Who is sponsoring the NCT07409493 clinical trial?
NCT07409493 is sponsored by Hanoi Medical University. The trial plans to enroll 148 participants.