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Recruiting NCT04335383

Isolation of Human Recombinant Therapeutic Monoclonal Anti-Pseudomonas Antibodies

Trial Parameters

Condition Pseudomonas Aeruginosa
Sponsor University Hospital, Grenoble
Study Type OBSERVATIONAL
Phase N/A
Enrollment 30
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2020-10-05
Completion 2026-10
Interventions
Isolation of anti-Pseudomonas antibodies from type B lymphocytes

Brief Summary

Pseudomonas aeruginosa is a pathogenic bacteria for human, especially in hospital settings. It can sometimes be multi-resistant to many or even to all antibiotics usually used for its treatment. The aim of the study is to isolate and produce therapeutic antibodies against the bacteria Pseudomonas aeruginosa in order to provide an alternative treatment to antibiotics in case of infection with an antibiotic-resistant strain of Pseudomonas aeruginosa.

Eligibility Criteria

Inclusion Criteria: * Patient selected in the retrospective part of the study (patient with serum containing functional anti-Pseudomonas aeruginosa antibodies) * Patient with weight ≥ 32kg. * With a follow-up visit at Grenoble University Hospital with a blood sampling for its care * Having given its written no objection to participate in the prospective phase of this project Exclusion Criteria: * Legally protected patient (minor, pregnant or nursing woman, ward or ward curated, hospitalized under duress or deprived of liberty)

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