NCT06842095 Investigating the Effects of Transcranial Stimulation to Advance Stroke Rehabilitation
| NCT ID | NCT06842095 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Oxford |
| Condition | Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-02-01 |
| Primary Completion | 2027-02-28 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2025-02-01 with a primary completion date of 2027-02-28.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Non-invasive brain stimulation (NIBS) has the potential to boost rehabilitation after stroke by creating a 'pro-plastic' environment, where the brain is more adaptable in response to movement (motor) training. However, responses to classical NIBS protocols are highly variable. Movement-related changes in specific brain rhythms have previously been shown to be related to recovery of hand/arm function after a stroke. The investigators propose to use NIBS to target movement-related activity in the beta band (13-30Hz) within the motor cortical regions of the brain. The investigators will use a type of NIBS called transcranial alternating current stimulation (tACS), which uses a sinusoidally-varying electrical current where the stimulation frequency is determined to be relevant to the underlying brain rhythms of interest, and the stimulation timed to coincide with specific phases of the hand/arm movement. The primary aim is to investigate whether beta-tACS improves upper limb movement in stroke survivors.
Eligibility Criteria
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Aged 18 years or above. * Clinical diagnosis of stroke affecting the upper limb, with sufficient ability to perform the upper limb reaching task. * At least 3 months post-stroke and discharged from inpatient care. Exclusion Criteria: * Inability to follow task instructions. * Other neurological condition affecting movement (e.g. Parkinson's Disease, Multiple Sclerosis). * Standard contraindications to non-invasive brain stimulation (TMS, tACS). including (but not limited to) the presence of intracranial metallic or magnetic hardware, seizures, pregnancy, and the presence of a pacemaker or other stimulators/implants. * Insufficient verbal and written English to comprehend the study and provide informed consent.
Contact & Investigator
Charlotte J Stagg, PhD
PRINCIPAL INVESTIGATOR
University of Oxford
Frequently Asked Questions
Who can join the NCT06842095 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06842095 currently recruiting?
Yes, NCT06842095 is actively recruiting participants. Contact the research team at melanie.fleming@ndcn.ox.ac.uk for enrollment information.
Where is the NCT06842095 trial being conducted?
This trial is being conducted at Oxford, United Kingdom.
Who is sponsoring the NCT06842095 clinical trial?
NCT06842095 is sponsored by University of Oxford. The principal investigator is Charlotte J Stagg, PhD at University of Oxford. The trial plans to enroll 60 participants.
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