NCT05911932 Investigating Genetic Status in Patients Presenting to Clinic
| NCT ID | NCT05911932 |
| Status | Recruiting |
| Phase | — |
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
| Condition | Dementia, Frontotemporal |
| Study Type | OBSERVATIONAL |
| Enrollment | 1,000 participants |
| Start Date | 2023-10-20 |
| Primary Completion | 2038-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 1,000 participants in total. It began in 2023-10-20 with a primary completion date of 2038-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The causes of neurodegenerative dementias such as Frontotemporal Dementia, Lewy Body Disease and Alzheimer's disease are still largely unknown. While the contribution of some genetic mutations and polymorphisms is associated with autosomal dominant patterns of inheritance of these dementias, in many cases, the specific causative mutation in these families is not yet identified. Further, in many patients, polygenic risk is thought to give rise to pathophysiologic changes, but which specific genes affect risk are largely yet unknown. By examining genotypes in patients that present to our Cognitive Neurology and Alzheimer's Research Clinic with suspected or confirmed neurodegenerative dementia, or have a history of a familial dementia, we aim to help identify and characterize genetic mutations or polymorphisms that give rise to neurodegenerative diseases.
Eligibility Criteria
Inclusion Criteria: * Persons presenting to the cognitive clinic with a neurodegenerative disorder (for example, AD, FTD, LBD, ALSP, and related conditions); * Biological family members of someone diagnosed with a neurodegenerative disorder, presenting to clinic; * Age 18+ years old; * Consenting to a blood draw. Exclusion Criteria: • Persons declining / unwilling / not able to have a blood draw.
Contact & Investigator
Elizabeth Finger, MD
PRINCIPAL INVESTIGATOR
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Frequently Asked Questions
Who can join the NCT05911932 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Dementia, Frontotemporal. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05911932 currently recruiting?
Yes, NCT05911932 is actively recruiting participants. Contact the research team at cognitiveneurology@sjhc.london.on.ca for enrollment information.
Where is the NCT05911932 trial being conducted?
This trial is being conducted at London, Canada.
Who is sponsoring the NCT05911932 clinical trial?
NCT05911932 is sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's. The principal investigator is Elizabeth Finger, MD at London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's. The trial plans to enroll 1,000 participants.