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Recruiting NCT06335719

NCT06335719 Intraoperative Electrical Stimulation to Improve Nerve Grafting Outcome

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Clinical Trial Summary
NCT ID NCT06335719
Status Recruiting
Phase
Sponsor The Cleveland Clinic
Condition Facial Paralysis
Study Type INTERVENTIONAL
Enrollment 20 participants
Start Date 2023-03-01
Primary Completion 2026-12-31

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age 80 Years
Study Type INTERVENTIONAL
Interventions
BESStandard of Care surgery

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.

This trial targets 20 participants in total. It began in 2023-03-01 with a primary completion date of 2026-12-31.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

A research study to find out if brief intraoperative electrical stimulation therapy improves nerve regeneration and smile outcomes following two-stage cross face nerve graft facial reanimation surgery.

Eligibility Criteria

Inclusion Criteria: 1. Patients 18-80 years-old with unilateral facial paralysis who are candidates for two- stage CFNG smile reanimation surgery (i.e. CFNG-driven free gracilis muscle transfer (FGMT) or dual innervation FGMT). 2. Agree to participate in the study. Exclusion Criteria: 1. Bilateral facial paralysis 2. Age less than 18 years-old or older than 80 years-old 3. Comorbid medical condition preventing two-stage CFNG surgery

Contact & Investigator

Central Contact

Hana Rosen, MD

✉ rosenh@ccf.org

📞 216-444-7018

Principal Investigator

Patrick Byrne, MD

PRINCIPAL INVESTIGATOR

The Cleveland Clinic

Frequently Asked Questions

Who can join the NCT06335719 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Facial Paralysis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT06335719 currently recruiting?

Yes, NCT06335719 is actively recruiting participants. Contact the research team at rosenh@ccf.org for enrollment information.

Where is the NCT06335719 trial being conducted?

This trial is being conducted at Cleveland, United States.

Who is sponsoring the NCT06335719 clinical trial?

NCT06335719 is sponsored by The Cleveland Clinic. The principal investigator is Patrick Byrne, MD at The Cleveland Clinic. The trial plans to enroll 20 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: September 2026  ·  Data Methodology