NCT05120635 Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
| NCT ID | NCT05120635 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Duke University |
| Condition | Fear |
| Study Type | INTERVENTIONAL |
| Enrollment | 80 participants |
| Start Date | 2021-10-01 |
| Primary Completion | 2026-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 80 participants in total. It began in 2021-10-01 with a primary completion date of 2026-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. The purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. These tasks will expose the participants to various levels of fear-provoking images. Participants with responsive neurostimulation (RNS) implants will be enrolled under Pro00117931 at Duke, but their results for fear and anxiety tasks will be reported under NCT05120635.
Eligibility Criteria
Inclusion Criteria: * 18 years of age or older * Has undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement * Willing to provide informed consent and participate in the study * Ability to read and write English fluently Exclusion Criteria: * Unwilling to provide informed consent * Has not undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement * Pregnant women * Participants with active psychosis * Participants with suicidal ideation * Participants with substance abuse issues
Contact & Investigator
Nanthia Suthana, PhD
PRINCIPAL INVESTIGATOR
Duke Health
Frequently Asked Questions
Who can join the NCT05120635 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 70 Years, studying Fear. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05120635 currently recruiting?
Yes, NCT05120635 is actively recruiting participants. Contact the research team at suthanalab@duke.edu for enrollment information.
Where is the NCT05120635 trial being conducted?
This trial is being conducted at Los Angeles, United States, Durham, United States.
Who is sponsoring the NCT05120635 clinical trial?
NCT05120635 is sponsored by Duke University. The principal investigator is Nanthia Suthana, PhD at Duke Health. The trial plans to enroll 80 participants.