NCT05791162 Interest of Follicular Helper Lymphocytes / Regulatory Follicular Helper Lymphocytes Ratio in IgA Nephropathy
| NCT ID | NCT05791162 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Centre Hospitalier Universitaire de Besancon |
| Condition | Glomerulonephritis, IGA |
| Study Type | INTERVENTIONAL |
| Enrollment | 75 participants |
| Start Date | 2023-05-23 |
| Primary Completion | 2026-05 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 75 participants in total. It began in 2023-05-23 with a primary completion date of 2026-05.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to investigate the relevance of the Tfh/Tfr (Follicular helper T cells/ Follicular regulatory T cells) ratio in patients with IgA nephropathy: * To identify a differential expression of the Tfh/Tfr ratio in patients considered stable or progressive * To predict, at diagnosis, the clinical evolution of the disease (progressive or stable form) in the first year.
Eligibility Criteria
Inclusion Criteria: * IgA nephropathy histologically proven on renal biopsy according to KDIGO criteria, with 8 permeable glomeruli (patients diagnosed from 2009 with a minimum follow-up for their nephropathy of 5 years (arm 1) or patients diagnosed during the study (arm 2)) Control patients: Lupus or ANCA-associated vasculitis or polycystic kidney disease (arm 3) Exclusion Criteria: * Legal incapacity or limited legal capacity * Subjects with no social security coverage. * Pregnancy / No effective contraceptive method
Contact & Investigator
Melchior Chabannes, MD
PRINCIPAL INVESTIGATOR
Nephrology, CHU Besançon
Frequently Asked Questions
Who can join the NCT05791162 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Glomerulonephritis, IGA. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05791162 currently recruiting?
Yes, NCT05791162 is actively recruiting participants. Contact the research team at cvauchy@chu-besancon.fr for enrollment information.
Where is the NCT05791162 trial being conducted?
This trial is being conducted at Besançon, France.
Who is sponsoring the NCT05791162 clinical trial?
NCT05791162 is sponsored by Centre Hospitalier Universitaire de Besancon. The principal investigator is Melchior Chabannes, MD at Nephrology, CHU Besançon. The trial plans to enroll 75 participants.