NCT07413718 Inspiratory Muscle Training in Amiotrophyc Lateral Sclerosis
| NCT ID | NCT07413718 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Ramon Llull |
| Condition | Amyotrophic Lateral Slerosis |
| Study Type | INTERVENTIONAL |
| Enrollment | 44 participants |
| Start Date | 2025-09-01 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 44 participants in total. It began in 2025-09-01 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Amyotrophic Lateral Sclerosis (ALS) progressively damages the nerve cells responsible for voluntary muscle movement. Over time, this leads to weakness in different muscles such as those used for movement or breathing. Breathing problems are one of the main causes of complications and reduced survival in people with ALS. This happens because the inspiratory muscles-those that help draw air into the lungs-gradually lose strength. The study has the aim to explore the benefits of training inspiratory muscles in ALS patients in order to maintain the setrength of these muscles for as long as possible and look the impact on respiratory function.
Eligibility Criteria
Inclusion Criteria: * Patients diagnosed with spinal ALS * men and women * diagnosis date less than two years ago, according to the "El Escorial" criteria (Appendix 2) * PIM above the lower limit of normal * Preserved lung function (FVC ≥ 80%, FEV1 ≥ 80%, FEV1/FVC ≥ 80%) and normal values in supine position Exclusion Criteria: * Patients with signs of respiratory muscle weakness (MIP and MEP below the LLN and abnormal decubitus tests19-21) * Nocturnal hypoventilation * Inability to perform the measurement tests * Inability to understand and perform the exercises * Any contraindication to the use of IMT. Severe psychiatric illness.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07413718 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 85 Years, studying Amyotrophic Lateral Slerosis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07413718 currently recruiting?
Yes, NCT07413718 is actively recruiting participants. Contact the research team at jordi.gestos@gmail.com for enrollment information.
Where is the NCT07413718 trial being conducted?
This trial is being conducted at Donostia / San Sebastian, Spain.
Who is sponsoring the NCT07413718 clinical trial?
NCT07413718 is sponsored by University Ramon Llull. The trial plans to enroll 44 participants.