NCT06475547 Inflammation and Postoperative Atrial Fibrillation in Cardiac Surgery
| NCT ID | NCT06475547 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Odense University Hospital |
| Condition | Atrial Fibrillation |
| Study Type | OBSERVATIONAL |
| Enrollment | 100 participants |
| Start Date | 2022-01-01 |
| Primary Completion | 2027-01-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 100 participants in total. It began in 2022-01-01 with a primary completion date of 2027-01-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, marked by an irregular and rapid heart rate, and associated with increased morbidity, longer hospital stays, and higher costs. Its complex pathophysiology involves atrial remodeling, inflammation, and autonomic dysregulation. Surgical trauma and cardiopulmonary bypass trigger an inflammatory response, releasing cytokines. Epicardial fat around the heart secretes pro-inflammatory cytokines, and its increased thickness is linked to higher inflammation and atrial fibrillation. This study uses RNA sequencing (RNA-seq) to profile gene expression in epicardial fat, identifying key genes involved in inflammation and metabolism. By comparing patients with and without POAF, RNA-seq reveals differentially expressed genes associated with postoperative atrial fibrillation.
Eligibility Criteria
Inclusion Criteria: * Age \> 18 * Informed consent Exclusion Criteria: * Incompetent individuals * General poor health condition at the time of inclusion * Reoperation
Contact & Investigator
Lytfi Krasniqi, MD
PRINCIPAL INVESTIGATOR
Odense University Hospital
Frequently Asked Questions
Who can join the NCT06475547 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 99 Years, studying Atrial Fibrillation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06475547 currently recruiting?
Yes, NCT06475547 is actively recruiting participants. Contact the research team at Lytfi.Krasniqi@rsyd.dk for enrollment information.
Where is the NCT06475547 trial being conducted?
This trial is being conducted at Odense, Denmark.
Who is sponsoring the NCT06475547 clinical trial?
NCT06475547 is sponsored by Odense University Hospital. The principal investigator is Lytfi Krasniqi, MD at Odense University Hospital. The trial plans to enroll 100 participants.
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