Incidence of Postoperative Cognitive Decline in Patients With Preexisting Cognitive Impairment
Trial Parameters
Brief Summary
This study aims to find out how often memory and thinking problems happen after surgery in people who already have memory issues before their operation. These memory problems are called postoperative cognitive decline (POCD). Older adults with memory problems before surgery may be more likely to have trouble with thinking, memory, and daily activities after their operation. This study will follow patients who already have memory problems before surgery and see how their thinking and memory change after surgery. The results will help doctors better understand how to care for these patients before, during, and after surgery.
Eligibility Criteria
1. Preexisting Cognitive Impairment (PreCI) Surgical Group Inclusion Criteria: * Age ≥ 60 years * Preoperative screening with MMSE and MoCA-B indicating mild cognitive impairment (MCI) or mild dementia * Undergoing elective non-cardiac surgery under general anesthesia Exclusion Criteria: * Expected difficulty in completing neuropsychological assessments (e.g., inability to communicate in Mandarin, blindness, or deafness) * Usual residence outside Shenzhen 2. Normative Reference Group Inclusion Criteria: * Age ≥ 60 years * No history of general anesthesia surgery within the past 12 months * Mini-Cog score \> 1 Exclusion Criteria: * Planned elective surgery under general anesthesia within the next 12 months * History of suspected or diagnosed cognitive impairment, or screening indicating cognitive impairment using MMSE and MoCA-B * Expected difficulty in completing neuropsychological assessments (e.g., inability to communicate in Mandarin, blindness, or deafness) * Usual residence outsid