NCT05056597 Incentive Processing and Learning in Anorexia Nervosa and Bulimia Nervosa
| NCT ID | NCT05056597 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of California, San Diego |
| Condition | Anorexia Nervosa |
| Study Type | OBSERVATIONAL |
| Enrollment | 252 participants |
| Start Date | 2022-05-26 |
| Primary Completion | 2027-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 252 participants in total. It began in 2022-05-26 with a primary completion date of 2027-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to investigate areas of the brain responsible for 'liking', 'wanting', and learning in adults with eating disorders using brain imaging techniques, computer tasks, a test meal, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 252 women with an eating disorder (63 AN-restricting type (AN-R), 63 AN-binge eating/purging type (AN-BP), 63 bulimia nervosa (BN)) and 63 healthy controls (HC) aged 18-39. Aim 1: To examine neural differences in 'liking' and 'wanting' in ED relative to HC. Aim 2: To examine differences in instrumental learning for reward and punishment in ED relative to HC. Aim 3: To examine how 'liking' and 'wanting' drive instrumental learning in ED and predict clinical symptoms at baseline and 1 year later. Exploratory Aim: To explore the associations of dopamine function, as measured by neuromelanin MRI (NM-MRI), with ED diagnosis and brain response to 'liking', 'wanting', and learning.
Eligibility Criteria
Inclusion Criteria: Eating Disorder Group: * Between the ages of 18 and 39 years old * Meet DSM-V criteria for AN-R, AN-BP, or BN Healthy Control Group: * Between the ages of 18 and 39 years old * Have maintained 85% to 120% ideal body weight since menarche Exclusion Criteria: All Groups: * Psychotic illness/other mental illness requiring hospitalization * Current dependence on drugs or alcohol defined by DSM IV criteria. Additionally, positive test results for drug use on the day of the scan, apart of marijuana, will result in cancelling or rescheduling the scan because acute use will impact MRI measures. * Physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight * Neurological disorder, neurodevelopmental disorder, or history of head injury with \>30 min loss of consciousness * Any contraindication to undergoing an MRI * Primary obsessive compulsive disorder or primary major depressive disorder Additional Exclusion Criteria for ED Group: -If taking
Frequently Asked Questions
Who can join the NCT05056597 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 39 Years, studying Anorexia Nervosa. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05056597 currently recruiting?
Yes, NCT05056597 is actively recruiting participants. Visit ClinicalTrials.gov or contact University of California, San Diego to inquire about joining.
Where is the NCT05056597 trial being conducted?
This trial is being conducted at La Jolla, United States.
Who is sponsoring the NCT05056597 clinical trial?
NCT05056597 is sponsored by University of California, San Diego. The trial plans to enroll 252 participants.