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Recruiting NCT05929508

Improving Mobility and Function Following Transfemoral Amputation: A Novel Approach to Reverse Volumetric Muscle Loss

Trial Parameters

Condition Traumatic Amputation of Lower Extremity
Sponsor University of Illinois at Chicago
Study Type INTERVENTIONAL
Phase N/A
Enrollment 30
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2024-04-01
Completion 2027-06-01
Interventions
Ischemic Preconditioning

Brief Summary

The purpose of this study is to investigate the relationship between thigh strength and walking ability and assess if using a blood pressure cuff on the leg improves strength and walking performance.

Eligibility Criteria

Inclusion Criteria: * At least 18 years old * History of lower limb unilateral transfemoral amputation. * At least two years post lower limb amputation * Able to ambulate independently without the use of aids (i.e., walking cane). * Able to walk at least 10 minutes continuously without stopping. * Has a safe residuum with no open wounds on either the residual or intact limb. * Has a prosthetic limb with materials that are sound and safe to withstand the mobility requirements of the study. Exclusion Criteria: * Younger than 18 years old. * Inability to give informed consent. * Neurological disorder that affects gait. * Participants with significant metal (greater than one orthopaedic screw) in either the residual limb or the sound/intact limb * Participants who begin taking medications or change dosage of medications that could affect gait, balance, and cardiovascular function during the course of the study. * Currently pregnant (or intend to become pregnant while participating in study

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