NCT06919003 Improving Deceased-Donor Kidney Transplant Outcomes Via a Single Intragraft Injection of C1 Esterase Inhibitor (IMPROVE TRIAL)
| NCT ID | NCT06919003 |
| Status | Recruiting |
| Phase | Phase 2 |
| Sponsor | National Institute of Allergy and Infectious Diseases (NIAID) |
| Condition | Kidney Transplant |
| Study Type | INTERVENTIONAL |
| Enrollment | 180 participants |
| Start Date | 2025-09-22 |
| Primary Completion | 2031-05-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 180 participants in total. It began in 2025-09-22 with a primary completion date of 2031-05-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to find out if Berinert can improve kidney function in the first year after transplant and to find out what effects, good or bad, Berinert will have in the kidney recipient. This research study will compare Berinert to placebo. The placebo looks exactly like Berinert but does not contain any active drug. Placebos are used in research studies to see if the results are due to the study drug or due to other reasons. Neither you or the study doctor can choose or know which group is assigned. The primary objective is to test whether intrarenal artery C1 esterase inhibitor (C1INH) injection into the donor kidney prior to transplantation improves kidney function in recipients of high risk, deceased donor kidney transplants as measured by 12-month Estimated Glomerular Filtration Rate (eGFR) Chronic Kidney Disease Epidemiology Collaboration (CDK-EPI)
Eligibility Criteria
Inclusion Criteria: 1. Participant must be able to understand and provide informed consent 2. Adults who are on chronic dialysis therapy and are on the wait list for deceased donor kidney transplant 3. Recipients who are ABO compatible with donor allograft 4. Negative crossmatch and no donor specific anti-HLA antibody (DSA) on most recent pretransplant serum sample as determined by local site 5. Female participants of childbearing potential must have a negative pregnancy test upon study entry 6. All participants with reproductive potential must agree to use highly effective contraception for at least 12-moths post-transplant. Oral estrogen containing contraception must not be used during the first 3 months post-transplant 7. Hepatitis C Virus Ab positive participants with negative Hepatitis C virus (HCV) Polymerase chain reaction (PCR) are eligible if they have spontaneously cleared infection or are in sustained virologic remission 8. Hepatitis C Virus negative recipients of a Hepatitis C Virus positive organ are eligible if they will be treated with the intent of inducing a sustained virologic remission 9. Recipients of kidneys arriving to the transplant center on ex vivo hypothermic machine perfusion pumps are eligible 10. Recipients of kidneys that received in situ normothermic regional perfusion in the donor are eligible. Kidneys that received normothermic machine perfusion after organ procurement (ex situ normothermic perfusion) are not eligible (See Exclusion #4) 11. Anticipated Cold Ischemia Time (CIT) \>=12 hours 12. Kidney Donor Profile Index (KDPI) 21-95%. For KDPI 21-34% to be eligible, anticipated CIT must be \>=24 hours 13. Patients with normal coagulation Exclusion Criteria: 1. Inability or unwillingness of a participant to give written informed consent or comply with study protocol 2. Any prior or concurrent non-renal solid organ, or cellular transplant, or waitlisted for multi-organ transplant. Prior autologous transplant is allowed 3. Patients receiving enbloc kidneys 4. Kidneys that received ex vivo normothermic machine perfusion after procurement. Kidneys that received in situ normotherimic regional perfusion in the donor are eligible (see Inclusion #10) 5. Patients with a known pro-thrombotic disorder 6. Patients with a history of thrombosis or hyper-coagulable state, excluding dialysis access clotting or other superficial vein thrombosis not requiring long-term systemic treatment 7. Body mass index (BMI) \>=40 kg/m\^2 8. Patients with a history of Hereditary Angioedema or use of C1 esterase inhibitor (C1INH) containing products or recombinant C1INH within 15 days prior to study entry 9. Patients with a known hypersensitivity to treatment with Berinert 10. Patients requiring chronic anti-coagulation or anti-platelet therapy. ASA and NSAIDS are allowed 11. Presence of active malignancy or history of malignancy less than 5 years in remission, excluding adequately treated in-situ cervical carcinoma, low grade prostate carcinoma, renal cell carcinoma stage T1N0M0 that has been treated with nephrectomy, or adequately treated basal or squamous cell carcinoma of the skin 12. Patients who are positive for Hep B infection (Hepatitis B surface antigen (HBsAg)+); patients with HbcAB+ are eligible if HBV PCR is negative 13. Any active infection 14. Human immunodeficiency virus (HIV) infection 15. Enrollment in another investigational trial 16. Recent recipient of any licensed or investigational live attenuated vaccine(s) within 4 weeks of enrollment 17. Current or planned use of immunomodulatory agents including but not limited to rituximab, belatacept, eculizumab, JAK inhibitors, anti-TNF agents 18. Female participants who are pregnant or lactating 19. Past or current medical problems, inclusive of mental health and substance abuse concerns, or findings from physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study 20. History of any stroke (including ischemic, hemorrhagic, or embolic) within the previous 6 months
Contact & Investigator
Peter S Heeger, MD
STUDY CHAIR
Cedars-Sinai Medical Center
Frequently Asked Questions
Who can join the NCT06919003 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Kidney Transplant. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06919003 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT06919003 currently recruiting?
Yes, NCT06919003 is actively recruiting participants. Visit ClinicalTrials.gov or contact National Institute of Allergy and Infectious Diseases (NIAID) to inquire about joining.
Where is the NCT06919003 trial being conducted?
This trial is being conducted at Los Angeles, United States, Chicago, United States, Kansas City, United States, The Bronx, United States.
Who is sponsoring the NCT06919003 clinical trial?
NCT06919003 is sponsored by National Institute of Allergy and Infectious Diseases (NIAID). The principal investigator is Peter S Heeger, MD at Cedars-Sinai Medical Center. The trial plans to enroll 180 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.