NCT07032363 Implementing Depression and Adherence Treatment
| NCT ID | NCT07032363 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Miami |
| Condition | Depression |
| Study Type | INTERVENTIONAL |
| Enrollment | 10 participants |
| Start Date | 2026-05-20 |
| Primary Completion | 2030-05 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 10 participants in total. It began in 2026-05-20 with a primary completion date of 2030-05.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to compare a core set and enhanced set of implementation strategies in increasing the reach of evidence-based treatments to patients with HIV and depression. The main questions it aims to answer are: What proportion of patients start an evidence-based treatment for depression (reach)? What percentage of patients show clinical improvement in depression and what percentage attain viral undetectability within one year (effectiveness)? Researchers will compare high and low reach clinics to further inform tailored implementation strategies for uptake and maintenance. Clinics will be randomized into one of two study arms: core versus enhanced strategies. In both arms, core strategies will be utilized. Enhanced clinics will also receive more resource-intensive training.
Eligibility Criteria
Inclusion Criteria for Clinics (the primary "participants"): * Clinics are eligible if they provide HIV primary care via the City of Cape Town (CoCT) Department of Health * Clinics will be assigned to the study upon notice of funding and before start up. Inclusion Criteria for Patient-level Outcomes: Although the unit of randomization is at the clinic level, the study will be looking at adult patient level data at each clinic. All patients engaged in care at one of the 10 primary care/HIV treatment clinics in the study will be included if they: * Are 18 years of age or older and * Have a detectable HIV viral load (operationalized as the lower limit of detection on the standard test is used at the local clinic), or presumed detectable viral load per clinic standards * Screen in for depression via the PHQ (following detection standards set in clinics) Exclusion Criteria: -Children below the age of 18 will not be included in the proposed study for adults.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07032363 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Depression. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07032363 currently recruiting?
Yes, NCT07032363 is actively recruiting participants. Contact the research team at ssafren@miami.edu for enrollment information.
Where is the NCT07032363 trial being conducted?
This trial is being conducted at Miami, United States, Boston, United States, Cape Town, South Africa.
Who is sponsoring the NCT07032363 clinical trial?
NCT07032363 is sponsored by University of Miami. The trial plans to enroll 10 participants.
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