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Recruiting NCT05880758

Impact of Yo-Yo Sleep on Cardiometabolic Health

Trial Parameters

Condition Cardiometabolic Syndrome
Sponsor Columbia University
Study Type INTERVENTIONAL
Phase N/A
Enrollment 72
Sex ALL
Min Age 18 Years
Max Age 49 Years
Start Date 2023-09-22
Completion 2027-12
Interventions
Intermittent Short Sleep (ISS)Social Jetlag (SJL)Sustained Adequate Sleep (SAS)

Brief Summary

The goal of this clinical trial is to test the impact of repeated intermittent short sleep, with short sleep maintained 5 days per week followed by 2 days of prolonged sleep, compared to daily adequate sleep, on energy balance and cardiometabolic risk. A secondary goal of this research is to determine if maintaining a constant midpoint of sleep while undergoing intermittent short sleep, leads to better outcomes than intermittent short sleep with a 2-hour delay in sleep midpoint. The aims of this research will be tested in the context of a 3-group, parallel-arm, outpatient intervention of 4 weeks in duration, in young-to-middle-aged adults (aged 18-49 years).

Eligibility Criteria

Inclusion Criteria: * Aged 18 to 49 years * BMI 20-29.9 kg/m2 * Habitually sleeping 7-9 hours/night without sleep aids or naps Exclusion Criteria: * Sleep disorders * Psychiatric disorders (including eating disorders) and seasonal affective disorder * Pregnancy (current/prior year) * Breastfeeding * Smokers (Any cigarette smoking or ex-smokers \<3years) * Diabetes * Elevated blood pressure, taking beta-blockers * Individuals taking anti-coagulants or anti-platelets * Recent weight change or participation in a weight loss program or have ever had bariatric surgery or other weight loss or gastrointestinal procedure. * Travel across time zones; shift work (non-traditional hours)

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