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Recruiting Phase 2 NCT04597372

Impact of Tamsulosin on Post-Operative Urinary Retention Following Pelvic Reconstructive Surgery

Trial Parameters

Condition Urinary Retention Postoperative
Sponsor Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Study Type INTERVENTIONAL
Phase Phase 2
Enrollment 154
Sex FEMALE
Min Age 18 Years
Max Age N/A
Start Date 2021-11-03
Completion 2026-12
Interventions
TamsulosinPlacebo

Brief Summary

The objective of the study is to determine the effectiveness of postoperative Tamsulosin in reducing the duration of acute postoperative urinary retention (POUR) following pelvic reconstructive surgery through a double blind, randomized placebo-controlled trial.

Eligibility Criteria

Inclusion Criteria: * 18 years or older * willing and able to provide informed consent * postoperative urinary retention as defined by a failed RGVT prior to hospital discharge * Ability to speak and read English * Tolerate pill ingestion Exclusion Criteria: * allergy/intolerance to Tamsulosin or sulfa drugs * preoperative history of urinary retention as defined by preoperative post void residual of \>150mL * current use of alpha antagonist medication for hypertension * severe dementia * end stage renal or liver disease * history of severe heart failure or major cardiovascular event in the last 6 months

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