NCT07452848 Impact of Pringle Maneuver on Postoperative Gallbladder Diseases After Hepatectomy
| NCT ID | NCT07452848 |
| Status | Recruiting |
| Phase | — |
| Sponsor | West China Hospital |
| Condition | Gallbladder Diseases |
| Study Type | OBSERVATIONAL |
| Enrollment | 2,000 participants |
| Start Date | 2026-03-01 |
| Primary Completion | 2026-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 2,000 participants in total. It began in 2026-03-01 with a primary completion date of 2026-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The liver is an organ with a rich blood supply. During liver surgery (hepatectomy), surgeons often temporarily clamp the blood vessels supplying the liver to maintain a clear surgical field and reduce bleeding. This common technique is known as the Pringle maneuver. However, this maneuver also temporarily cuts off the blood supply to the gallbladder. Currently, doctors debate whether to routinely remove a healthy gallbladder during liver surgery to prevent future gallbladder problems, or to preserve it. The primary purpose of this multicenter retrospective cohort study is to evaluate whether using the Pringle maneuver during liver surgery increases the risk of patients developing gallbladder diseases (such as gallstones or inflammation) later on. Researchers will review the past medical records of patients who underwent liver surgery with their gallbladder preserved between January 2012 and January 2022. By comparing patients who had the Pringle maneuver with those who did not, the study aims to provide reliable clinical evidence to help surgeons make better decisions about whether to preserve or remove the gallbladder during liver surgery.
Eligibility Criteria
Inclusion Criteria: * Aged 18 to 85 years. * Definitive diagnosis of hepatic solid lesions confirmed by imaging (such as CT, MRI, or ultrasound) and/or pathology. * Underwent elective hepatectomy with gallbladder preservation. * Preoperative liver function evaluated as Child-Pugh class A or B. * Preoperative American Society of Anesthesiologists (ASA) physical status classification of I, II, or III. Exclusion Criteria: * Preoperative evaluation indicating pre-existing biliary tract diseases (e.g., cholelithiasis, biliary inflammation, neoplastic lesions). * History of previous upper abdominal surgery. * Application of non-hepatic inflow occlusion methods during surgery (e.g., hemihepatic vascular occlusion, selective segmental vascular occlusion). * Personal history of long-term use of hormone replacement therapy, somatostatin and its analogues, or oral contraceptives. * Loss to follow-up or missing critical data postoperatively.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07452848 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 85 Years, studying Gallbladder Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07452848 currently recruiting?
Yes, NCT07452848 is actively recruiting participants. Contact the research team at huangjiwei@wchscu.cn for enrollment information.
Where is the NCT07452848 trial being conducted?
This trial is being conducted at Hefei, China, Chongqing, China, Guangzhou, China, Guangzhou, China and 4 additional locations.
Who is sponsoring the NCT07452848 clinical trial?
NCT07452848 is sponsored by West China Hospital. The trial plans to enroll 2,000 participants.