Impact of Gut Microbiome on Metabolic and Bowel Function During the First Year After Spinal Cord Injury
This study examines how bacteria in the gut may affect metabolism and bowel function during the first year after a spinal cord injury. Participants will provide blood and stool samples at baseline, 6 months, and 12 months after their injury to help researchers understand these connections.
Key Objective: This trial aims to identify how gut microbiome changes after spinal cord injury might influence metabolic health and bowel function, potentially leading to better management strategies.
Who to Consider: People who have experienced a spinal cord injury within the past 6 weeks and are interested in contributing to research that may improve long-term health outcomes after SCI should consider enrolling.
Trial Parameters
Brief Summary
The Investigators will recruit 35 participants with acute SCI (within 6 weeks of injury) Fasting blood collection and bowel function survey will be conducted 3 times: at baseline \[within 6 weeks of injury\], 6, and 12 months after SCI. Stool will be collected for gut microbiome analysis 3 times.
Eligibility Criteria
Inclusion Criteria: 1. 18-85 years of age 2. diagnosis of traumatic SCI at the cervical to lumbar level (C3-L2) 3. classification of A, B, C (motor complete, incomplete). Exclusion Criteria: 1. Women who are pregnant prior to consent 2. neurological impairment other than SCI 3. self-reported history of Crohn's disease or diverticulitis 4. irritable bowel syndrome 5. gastric blockage/obstruction or swallowing disorder 6. prior GI surgery 7. intrathecal pump 8. concurrent usage of functional electrical stimulation for bowel management (e.g., constipation). 9. able to ambulate