NCT05981612 Impact of Emotional Reactivity on Dysfunctional Decision-Making in NSSI Adolescents
| NCT ID | NCT05981612 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Electronic Science and Technology of China |
| Condition | Nonsuicidal Self Injury |
| Study Type | OBSERVATIONAL |
| Enrollment | 80 participants |
| Start Date | 2023-12-06 |
| Primary Completion | 2026-07 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 80 participants in total. It began in 2023-12-06 with a primary completion date of 2026-07.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Studies revealed that dysfunctional interpersonal relationships and reward-related decision-making may play crucial roles in this maladaptive behavior, especially in adolescents. These interpersonal decision contexts are characterized by constant updating of expectations of rewards and the actual received rewards as well as the associated emotional reactions. These processes have recently been computationally formalized as prediction errors (PE), specifically reward PEs, valence PEs, and arousal PEs (Heffner et al., 2021; Nat Hum Behav). In the current study, the investigators aim to investigate whether these PEs make discernible contributions to social decisions in the context of unfair experiences among adolescents with NSSI and matched healthy control adolescents (HC). Specifically the investigators hypothesized that: 1) reward and emotional PEs show significant predictions of punishment decisions in both groups, 2) however, compared to HC adolescents, the NSSI group will exhibit selective dysfunctions in emotional but not reward PEs leading to punish a norm proposer who provided unfair offers.
Eligibility Criteria
Inclusion Criteria: * 15-18 years * right-handed * normal or corrected normal visual acuity * meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year) Exclusion Criteria: * diagnosis of borderline personality disorder, major depressive disorder, other * psychiatric disorders, etc. * high suicidal risk * recent use of medications that can affect neural activity * have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months * have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05981612 clinical trial?
This trial is open to participants of all sexes, aged 15 Years or older, up to 18 Years, studying Nonsuicidal Self Injury. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05981612 currently recruiting?
Yes, NCT05981612 is actively recruiting participants. Contact the research team at ben_becker@gmx.de for enrollment information.
Where is the NCT05981612 trial being conducted?
This trial is being conducted at Chengdu, China.
Who is sponsoring the NCT05981612 clinical trial?
NCT05981612 is sponsored by University of Electronic Science and Technology of China. The trial plans to enroll 80 participants.