Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients
Trial Parameters
Brief Summary
Advanced age is a consistent risk factor for the incidence of postoperative cognitive decline, which is associated with longer hospital stays, decreased quality of life, and increased mortality. Anaesthetic drugs can also affect postoperative cognition, as their residual effects can alter central nervous system activity. Desflurane and sevoflurane are widely used volatile anesthetics. Choice anesthetics may influence the occurrence of postoperative delirium. However, evidence in this aspect is conflicting.
Eligibility Criteria
Inclusion Criteria: 1. Age ≥ 65 years and \< 90 years; 2. Scheduled to undergo non-cardiac or non-neurosurgery with an expected duration of 2 hours or more, under general anesthesia; 3. Agree to participate, and give signed written informed consent. Exclusion Criteria: 1. Preoperative history of schizophrenia, epilepsy, parkinsonism or any diseases of central nervous system; 2. Inability to communicate in the preoperative period (coma, dementia, language barrier, impaired hearing or vision); 3. Severe diseases in cardiovascular, respiratory, liver, kidney, or preoperative American Society of Anesthesiologists physical status classification ≥ IV; 4. Alcoholism and drug dependence; 5. Other reasons that are considered unsuitable for participation by the responsible surgeons or investigators (reasons must be recorded in the case report form).