NCT06652126 Immunosuppression and Intensive Care Unit-acquired Multidrug-resistant Bacteria
| NCT ID | NCT06652126 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital, Lille |
| Condition | Critically-ill Patients |
| Study Type | OBSERVATIONAL |
| Enrollment | 1,000 participants |
| Start Date | 2025-03-19 |
| Primary Completion | 2029-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 1,000 participants in total. It began in 2025-03-19 with a primary completion date of 2029-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Antimicrobial resistance AMR is an emerging global threat to human health, and intensive care units (ICUs) are a 'hot spot' for the emergence and diffusion of multidrug-resistant (MDR) bacteria. ICU-acquired colonization and infection with MDR bacteria (ICU-MDR-col and ICU-MDR-inf, respectively) have been associated with higher ICU length-of-stay, duration of invasive mechanical ventilation and mortality. Immunocompromised patients account for an increasing proportion of ICU patients, and they are particularly prone to ICU-acquired infections, a significant proportion of which are caused by MDR pathogens. Recently, in a prospective multicenter study in France (CIMDREA, 8 ICUs, 750 patients), we found that immunocompromised patients had a lower cumulative incidence of ICU-MRD-col, but not ICU-MDR-inf (after adjustment for confounders). These results suggest that isolation measures and contact precautions could have a protective impact on cross-transmission of MDR bacteria in immunocompromised patients, even though our study fails to provide conclusive arguments for this. If confirmed, these findings could have an impact on antibiotic stewardship in immunocompromised critically-ill patients, a key element to control the spread of AMR in ICUs and beyond. Thus, we are planning to carry out the TANGERINE study, an observational prospective multicenter study in Europe, to confirm the findings of CIMDREA and provide a better understanding of the effect of isolation measures and contact precautions on the epidemiology of AMR in ICUs.
Eligibility Criteria
Inclusion Criteria: 1. Patients aged 18 and over. 2. Admitted to intensive care and whose length of stay is greater than 48 hours (inclusion is at the 48th hour after admission). 3. Immunocompetent OR immunocompromised patients according to one of the following criteria: 1. Solid cancer under treatment or in remission for less than 5 years (including cancers diagnosed during hospitalization in intensive care); 2. Hematological malignancies under treatment or in remission for less than 5 years (including hematological malignancies diagnosed during hospitalization in intensive care); 3. Neutropenia \< 0.7 G/L for ≥ 7 days; 4. Solid organ transplants; 5. Patients with systemic or transplant pathologies requiring treatment with corticosteroids (prednisone equivalent \> 10 mg/day) or other high-dose immunosuppressants for \> 28 days; 6. Human Immunodeficiency Virus (HIV) infection with CD4+ \<200 μL; 7. Genetic immune deficiency. 4. Patients undergoing invasive mechanical ventilation and/or vasopressive amines. 5. Persons who have given their non-opposition. For patients unable to give their non-opposition, this will be obtained from the trusted support person. The patient will be informed as soon as possible and asked to agree to participate in any further research. 6. Patients affiliated to a social security system. Exclusion Criteria: 1. Minor patients (\< 18 years), 2. Length of stay in intensive care less than 48 hours, 3. Moribund patients. 4. Absence of BMR screening (rectal swab routinely, combined with nasal swab in some centers) within 48 hours of admission. 5. Refusal to participate in the study. 6. Vulnerable and/or susceptible patients according to one of the following criteria: 1. Patients under legal protection (guardianship, curatorship, etc.); 2. Patients in prison; 3. Pregnant or breast-feeding women. 7. Patients without social security coverage. 8. Simultaneous participation in another interventional study that could interfere with the evaluation of primary and secondary endpoints (particularly in the case of participation in an interventional study that could modulate the risk of CAR or BMR-ARI).
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06652126 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Critically-ill Patients. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06652126 currently recruiting?
Yes, NCT06652126 is actively recruiting participants. Contact the research team at saadalla.nseir@chu-lille.fr for enrollment information.
Where is the NCT06652126 trial being conducted?
This trial is being conducted at Lille, France.
Who is sponsoring the NCT06652126 clinical trial?
NCT06652126 is sponsored by University Hospital, Lille. The trial plans to enroll 1,000 participants.