NCT05104502 Immunomodulatory Effects of Fasting in Healthy Adults
| NCT ID | NCT05104502 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of California, Davis |
| Condition | Fasting |
| Study Type | INTERVENTIONAL |
| Enrollment | 4 participants |
| Start Date | 2022-03-25 |
| Primary Completion | 2026-06 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 4 participants in total. It began in 2022-03-25 with a primary completion date of 2026-06.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a clinical trial assessing the effects of fasting on the immune system in healthy adults. Immune profiling, gene expression profiling, and flow cytometry on peripheral blood mononuclear cells (PBMCs) will be performed and we hypothesize that a period of fasting will alter the immune system in healthy adults.
Eligibility Criteria
Inclusion Criteria: * Age: 20-40 years, to constitute a young study population * Gender: male subjects, to control for gender differences * BMI: 19-27 kg/m2 to constitute a normal/healthy weight population * Weight: 120 lbs or more * Fasting glucose: 70-100 mg/dL, to ensure that fasting can be tolerated without inducing dangerously low levels of blood glucose * Subjects must be willing to undergo a period of 36 hours of water-only fasting * Subjects must be willing to collect samples of each bowel movement produced throughout the entire study period for microbiome analysis * Subjects must be willing to collect blood pricks for blood glucose levels using a Contour Next One Blood Glucose Testing Kit during the fasting stage of the study protocol. Exclusion Criteria: * Current smoking * Anemia * Pregnancy or current breastfeeding * Chronic diseases including diabetes mellitus, thyroid disease, metabolic syndrome, cancer, or previous cardiovascular events * Gastrointestinal diseases including irritable bowel syndrome, Crohn's disease, ulcerative colitis, celiac disease * Consumption of \>1 alcoholic drink/day * Extreme dietary or exercise patterns * Recent weight fluctuations (greater than 10% in the last six months) * Regular use of over-the-counter allergy or pain medications (\>1/week) * Taking prescription lipid medications (e.g. statins) or other supplements known to alter lipoprotein metabolism such as isoflavones * Use of hormonal birth control including oral contraception pills, hormonal IUDs or rings, or hormonal birth control patches
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05104502 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, up to 40 Years, studying Fasting. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05104502 currently recruiting?
Yes, NCT05104502 is actively recruiting participants. Contact the research team at ajixu@ucdavis.edu for enrollment information.
Where is the NCT05104502 trial being conducted?
This trial is being conducted at Sacramento, United States.
Who is sponsoring the NCT05104502 clinical trial?
NCT05104502 is sponsored by University of California, Davis. The trial plans to enroll 4 participants.