NCT06945861 Immunological Aspect of Thrombotic Thrombocytopenic Purpura (TTP)
| NCT ID | NCT06945861 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital, Rouen |
| Condition | Thrombotic Thrombocytopenic Purpura (TTP) |
| Study Type | OBSERVATIONAL |
| Enrollment | 44 participants |
| Start Date | 2023-05-11 |
| Primary Completion | 2027-05-10 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 44 participants in total. It began in 2023-05-11 with a primary completion date of 2027-05-10.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The general objective of the proposed project is to characterise phenotypically and functionally ADAMTS13-specific memory B lymphocytes and autoreactive T lymphocytes, in particular follicular helper T lymphocytes, in the acute phase of the disease, but also during its progression after treatment. The aim is to highlight their contribution to the initial pathogenic process, their evolution under treatment, and also their involvement in patients who are refractory to immunosuppressive therapies and during relapses. The aim of this project is to identify early phenotypic or functional parameters that are predictive of relapse and that can be used for personalised optimisation of treatment to maintain remission.
Eligibility Criteria
Inclusion Criteria: * age over 18 * patients with TTP at any stage of diagnosis (acute phase, lasting remission or not, relapse) * patients undergoing internal medicine at Rouen University Hospital * people who have read and understood the information letter * membership of a social security scheme Exclusion Criteria: \- a person deprived of liberty by an administrative or judicial decision or a person placed under court protection/guardianship or guardianship
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06945861 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Thrombotic Thrombocytopenic Purpura (TTP). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06945861 currently recruiting?
Yes, NCT06945861 is actively recruiting participants. Contact the research team at david.mallet@chu-rouen.fr for enrollment information.
Where is the NCT06945861 trial being conducted?
This trial is being conducted at Rouen, France.
Who is sponsoring the NCT06945861 clinical trial?
NCT06945861 is sponsored by University Hospital, Rouen. The trial plans to enroll 44 participants.