Trial Parameters
Brief Summary
This is a single center, single arm exploratory imaging study involving up to two intravenous microdoses of \[18F\]F-AraG (the second tracer dose is optional) followed by whole-body PET-CT imaging in participants with convalescent COVID-19. Up to 80 participants will be enrolled over an accrual period of approximately 48 months.
Eligibility Criteria
Inclusion Criteria: * Age \>18 years * Ability to read and understand written informed consent document * Have a recent diagnosis of SARS-CoV-2 infection as defined by a prior positive SARS-CoV-2 nucleic acid-based diagnostic test performed in a clinical laboratory on one or more nasopharyngeal or respiratory secretion samples. * \> 14 days since onset of COVID-19 symptoms (or if no symptoms, from time of initial nucleic acid based diagnostic test). * Laboratory evaluations obtained within 60 days prior to entry. * Platelet count ≥75,000/mm3 * ANC \>1000/mm3 * Aspartate aminotransferase (AST) \<3 x ULN * Alanine aminotransferase (ALT) \<3 x ULN * Calculated creatinine clearance (CrCl) ≥60 mL/min as estimated by the Cockcroft- * Gault equation Exclusion Criteria: * Any medical condition that would compromise the imaging acquisition, in the opinion of the investigator * Participants who are pregnant (female participants of childbearing age will be tested prior to injection of imaging age