NCT06805045 Image-Guided Surgery In The Treatment Of Rectal Cancer (AR_CRC)
| NCT ID | NCT06805045 |
| Status | Recruiting |
| Phase | — |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna |
| Condition | Rectum Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2024-05-29 |
| Primary Completion | 2026-10-01 |
Eligibility & Interventions
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2024-05-29 with a primary completion date of 2026-10-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The proposed study is addressed to introduce new Image-Guided Surgery (IGS) tools to assist mini-invasive surgical procedures of anterior rectal resection (TME; TA-TME, TTSS) performed with laparoscopic or robotic procedure. In details, the idea is to provide augmented reality (AR) guidance during robotic-assisted and laparoscopic surgeries, by overlaying the preoperative 3D virtual anatomical models to intraoperative surgical images (3D AR guidance). To optimize the intraoperative view during the 3D AR guidance, AI-based algorithms will be developed to allow the real time detection and segmentation of surgical instruments, needed to provide instrument de-occlusion during AR robotic surgery. We use 3D modelling technology in surgical planning (7 case) and intra-operative navigation ( 2 cases). The pilot study focused to 3D virtual reconstruction of the pelvis, rectum and neurovascular structure to the test the feasibility of virtual reality to this type of anatomy. Implementation of reconstruction using 3D nerve sequence (3 Tesla MRI) was used for the last 3 cases. After the creation of a complete virtual model of pelvis and its structures the last two models were applied in the operating-room during a laparoscopic rectal resection with the ausilium of AI. The test has showed good results: a good overlap of the 3D structures to the real organs of the pelvis. The focus of this research was on developing support tools aimed at enhancing surgical safety. AR can assist surgeons in identifying vascular and nerve structures that are not always clearly visible during minimally invasive procedures, compensating for the lack of tactile perception and thereby improving overall surgical safety. The next step of the study is to evaluate its benefits and limitations in clinical practice to reduce the post-operative complications and oncological recurrence.
Eligibility Criteria
Inclusion Criteria: * Indication for radical transabdominal surgery for primary rectal cancer * Resection and anastomosis or abdominal-perineal amputation surgery * Signature of informed consent * Patient's age ≥18 years. * CT images acquired in the arterial venous and urographic phase with section thickness:1.25/2.5 mm, level range:0.8/0.2 mm. * Pelvic MRI images acquired with section thickness of 1.5 mm or images acquired with 3 tesla MRI. Exclusion Criteria: * Patients who have already undergone previous rectal surgery * Relapse of previous rectal neoplasm * Neoplasm located in other pelvic organs, infiltrating the rectum * Indication for endoscopic or transanal treatment * Disease with peritoneal localisation (carcinosis) * Surgery for palliative purposes * Imaging performed elsewhere
Contact & Investigator
matteo rottoli, MD
PRINCIPAL INVESTIGATOR
IRCCS Azienda Osperaliero-Universitaria di Bologna
Frequently Asked Questions
Who can join the NCT06805045 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Rectum Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06805045 currently recruiting?
Yes, NCT06805045 is actively recruiting participants. Contact the research team at angela.belvedere@aosp.bo.it for enrollment information.
Where is the NCT06805045 trial being conducted?
This trial is being conducted at Bologna, Italy.
Who is sponsoring the NCT06805045 clinical trial?
NCT06805045 is sponsored by IRCCS Azienda Ospedaliero-Universitaria di Bologna. The principal investigator is matteo rottoli, MD at IRCCS Azienda Osperaliero-Universitaria di Bologna. The trial plans to enroll 50 participants.
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