Trial Parameters
Brief Summary
Panic disorder (PD) is characterized by recurrent and unexpected panic attacks and is associated with significant functional impairment. Increasing evidence suggests involvement of immune-inflammatory mechanisms in PD. Elevated levels of inflammatory markers such as C-reactive protein (CRP) have been reported in PD; however, interleukin-33 (IL-33) and soluble suppressor tumorogenicity-2 (sST2), components of the IL-33/sST2 signaling axis, have not previously been investigated in PD. This cross-sectional case-control study aims to compare peripheral serum IL-33, sST2, and CRP levels between drug-naïve subjects diagnosed with PD and healthy controls (HCs). The findings may contribute to understanding the inflammatory mechanisms underlying PD.
Eligibility Criteria
1. For Panic Disorder (PD) Group: \*Inclusion Criteria: * Being between 18-65 years of age * Having a diagnosis of panic disorder (PD) according to DSM-5-TR and having presented to the hospital with panic attack symptoms of the disorder * Not having previously used any medication for psychiatric purposes (drug-naive) * Not having any additional active psychiatric disorders besides PD at the current presentation * Absence of hypertension, diabetes mellitus, renal failure, hepatic failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, or cancer * Not having taken any medication or supplements in the last month * Completing sociodemographic and scale data fully * Volunteering to participate in the study For PD Group: \*Exclusion Criteria: • Being outside the 18-65 age range • Not meeting the diagnostic criteria for PD according to DSM-5-TR or being in good health • Having a history of psychiatric medication use • Having an additional psych