Identification of Fecal Microbiota Biomarkers of Spondyloarthritis in Patients Suffering From Crohn's Disease.
This research study examines the gut bacteria in people with Crohn's disease to identify specific microbial patterns that may be linked to the development of spondyloarthritis, a type of joint inflammation. Researchers will compare gut bacteria, immune factors in blood, and immune cells between patients with Crohn's disease alone, those with joint inflammation alone, and those with both conditions.
Key Objective: This trial may help identify bacterial biomarkers that could improve early detection and understanding of how Crohn's disease and spondyloarthritis are connected.
Who to Consider: People with Crohn's disease, with or without joint pain and inflammation, who are interested in contributing to research that may advance understanding of these linked conditions.
Trial Parameters
Brief Summary
The MICROSPA project aims to compare gut microbiota, serum cytokines, and PBMC of patients suffering from Crohn's disease (CD) associated or not to spondylarthritis (SpA). 3 groups of patients will be analyzed: patients suffering from CD alone, patients suffering from SpA alone, patients suffering from CD and SpA. One group of healthy controls will be analysed as a comparator. Fecal microbiota will be determined by bacteriome, virome and fungome NGS sequencing
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years. * Patients will be recruited according to 3 groups: * Patients with Crohn's disease and axial spondyloarthritis according to the criteria below. * Patients with Crohn's disease (MC patients) with a diagnosis established according to clinical, biological criteria, radiological, endoscopic and / or histological studies for 3 months. With diagnosis of exclusion of a spondyloarthritis on criteria ASAS and / or New York modified. * Patients with axial spondyloarthritis (SpA patients) with a diagnosis based on modified ASAS and / or New York criteria with exclusion diagnosis of Crohn's disease. * Patient with the ability to give free and express informed consent. Exclusion Criteria: * History of colonic resection * Taking antibiotics or colon preparation for colonoscopy within 8 weeks before stool collection (Temporary contraindication = removal possible before colic or first bowel preparation after the start of colonic preparation). * Ostomy at the time