NCT07088510 Hysteroscopic Resection Versus Manual Vacuum Aspiration for Early Pregnancy
| NCT ID | NCT07088510 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospitals Cleveland Medical Center |
| Condition | Miscarriage in First Trimester |
| Study Type | INTERVENTIONAL |
| Enrollment | 80 participants |
| Start Date | 2025-03-31 |
| Primary Completion | 2027-04-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 80 participants in total. It began in 2025-03-31 with a primary completion date of 2027-04-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Early pregnancy loss happens when a pregnancy that is not developing properly is found on an ultrasound before 12 weeks and 6 days. This type of loss occurs in about 10% of pregnancies. There are three main ways to treat this: waiting for it to pass naturally, using medication, or having surgery. Surgery is the most effective, working 99% of the time, compared to waiting (80% effective in 8 weeks) and medication (71-84% effective). Currently, surgery involves dilation of the cervix and curettage (removal of pregnancy tissue) with suction provided either from a manual hand-held pump or a machine. For the purposes of this study, a manual vacuum aspirator (or hand-held pump) will be used with ultrasound guidance. There is also another method called hysteroscopic resection, where the doctor uses a special camera to directly see and remove any pregnancy tissue from your uterus. Patients often want the quickest way to resolve the pregnancy loss, and physicians are unsure which surgical method is the best. It's also unclear if one type of surgery causes less scar tissue inside the uterus, affects the ability to test the tissue for genetic issues, or impacts how soon a patient can start fertility treatments again. This study aims to find out if hysteroscopic resection provides faster resolution and creates less scar tissue compared to the manual vacuum aspiration.
Eligibility Criteria
Inclusion Criteria: * Adult women age 18-55 * Ultrasound Diagnosis of Early Pregnancy Loss * \< 9 weeks gestational age as determined by ultrasound * Singleton non-viable pregnancy * Stated and willingness to comply with all study procedures and availability for the duration of the study * Provision of signed and dated informed consent form * Chose a surgical method of management for fetal loss Exclusion Criteria: * Pregnancy of Unknown Location * Current, viable pregnancy * Prior medical treatment for this early pregnancy loss * Contraindications to surgical management * Active infection (i.e. fever, chills, fundal tenderness) * Pre-existing coagulopathies
Contact & Investigator
Joseph Findley, MD
PRINCIPAL INVESTIGATOR
University Hospitals
Frequently Asked Questions
Who can join the NCT07088510 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 55 Years, studying Miscarriage in First Trimester. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07088510 currently recruiting?
Yes, NCT07088510 is actively recruiting participants. Contact the research team at kylie.phillips@uhhospitals.org for enrollment information.
Where is the NCT07088510 trial being conducted?
This trial is being conducted at Cleveland, United States.
Who is sponsoring the NCT07088510 clinical trial?
NCT07088510 is sponsored by University Hospitals Cleveland Medical Center. The principal investigator is Joseph Findley, MD at University Hospitals. The trial plans to enroll 80 participants.