NCT04271878 Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome
| NCT ID | NCT04271878 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Calgary |
| Condition | Postural Tachycardia Syndrome |
| Study Type | INTERVENTIONAL |
| Enrollment | 26 participants |
| Start Date | 2022-02-02 |
| Primary Completion | 2029-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 26 participants in total. It began in 2022-02-02 with a primary completion date of 2029-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The mechanism behind postural orthostatic tachycardia syndrome (POTS) involves many causes including a sympathetic nervous system problem. Blood gases, like carbon dioxide (CO2), have an important effect on sympathetic activation. The purpose of this research study is to determine if higher CO2 levels have any effect in lowering heart rate and reducing POTS symptoms when upright/standing. The investigators are also searching for the ideal CO2 concentration to achieve the most effective response
Eligibility Criteria
Inclusion Criteria: * Physician diagnosis of Postural Tachycardia Syndrome (POTS) * Age 18-60 years * Male and Female * Non - smokers. * Able and willing to provide informed consent. * Ability to travel to Libin Cardiovascular Institute of Alberta Autonomic Testing Lab at the University of Calgary, Calgary, AB. Exclusion Criteria: * Overt cause for postural tachycardia, i.e., acute dehydration * Participants with somatization or severe anxiety symptoms will be excluded * Pregnant * Inability to tolerate mask for the duration of the study * Subjects who require portable oxygen at rest or with exercise * Subjects with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath. * Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies.
Contact & Investigator
Satish R Raj, MD, MSCI
PRINCIPAL INVESTIGATOR
University of Calgary, Cardiac Science
Frequently Asked Questions
Who can join the NCT04271878 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Postural Tachycardia Syndrome. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04271878 currently recruiting?
Yes, NCT04271878 is actively recruiting participants. Contact the research team at shaun.ranada@ucalgary.ca for enrollment information.
Where is the NCT04271878 trial being conducted?
This trial is being conducted at Calgary, Canada.
Who is sponsoring the NCT04271878 clinical trial?
NCT04271878 is sponsored by University of Calgary. The principal investigator is Satish R Raj, MD, MSCI at University of Calgary, Cardiac Science. The trial plans to enroll 26 participants.