NCT07225660 Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
| NCT ID | NCT07225660 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Shady Grove Fertility Reproductive Science Center |
| Condition | Fertility Preservation |
| Study Type | INTERVENTIONAL |
| Enrollment | 394 participants |
| Start Date | 2026-02-25 |
| Primary Completion | 2027-06-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 394 participants in total. It began in 2026-02-25 with a primary completion date of 2027-06-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or immediate start (without a pause).
Eligibility Criteria
Inclusion Criteria: 1. Ovary-bearing individuals 18 to 40 years of age. 2. BMI \< 40 kg/m2 3. Non-smoker for at least 3 months prior to study enrollment. Exclusion Criteria: 1. BMI greater than or equal to 40 kg/m2 2. Current Smoker 3. Any contraindications to ovarian stimulation or outpatient egg retrieval under anesthesia
Frequently Asked Questions
Who can join the NCT07225660 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 40 Years, studying Fertility Preservation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07225660 currently recruiting?
Yes, NCT07225660 is actively recruiting participants. Visit ClinicalTrials.gov or contact Shady Grove Fertility Reproductive Science Center to inquire about joining.
Where is the NCT07225660 trial being conducted?
This trial is being conducted at Orange, United States, Rockville, United States, New York, United States.
Who is sponsoring the NCT07225660 clinical trial?
NCT07225660 is sponsored by Shady Grove Fertility Reproductive Science Center. The trial plans to enroll 394 participants.