| NCT ID | NCT06951919 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Dartmouth-Hitchcock Medical Center |
| Condition | Multiple Sclerosis |
| Study Type | INTERVENTIONAL |
| Enrollment | 125 participants |
| Start Date | 2025-09-09 |
| Primary Completion | 2028-05 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 125 participants in total. It began in 2025-09-09 with a primary completion date of 2028-05.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-MS to improve the quality of life and cognitive function in Service Members, Veterans and civilians who have multiple sclerosis with cognitive and memory problems (MS participants). This study will also assess the ability of the HOBSCOTCH-MS program to improve quality of life in caregivers of patients with multiple sclerosis and to reduce caregiver burden. Enrolling with a Caregiver is optional for MS participants. Investigators will compare two groups of MS participants and their Caregiver (enrolling with a Caregiver is optional): one who receives HOBSCOTCH-MS immediately (Group 1) and another group that will receive HOBSCOTCH-MS (Group 2) after a 3-month waiting period. Participants will be in the study for about 6 months total. HOBSCOTCH-MS involves 45 to 60 minute one on one virtual sessions with a certified Cognitive Coach including a "pre" program session and 8 weekly sessions thereafter. Participants will learn about problem solving therapy and mindfulness or relaxation training. MS participants are asked to do short homework assignments and both MS and Caregiver participants are asked to keep a brief daily diary on a smart phone app. All participants complete study questionnaires or surveys at enrollment, 3 months later and at 6 months (at the end of the study). After completing the intervention, MS Participants and their Caregivers may also participate in an optional one-time Key Informant Interview for qualitative analysis in an effort to further adapt and improve the HOBSCOTCH-MS in the future.
Eligibility Criteria
Inclusion Criteria: * Inclusion Criteria - MS Participant * Age 20 - 75 years * Diagnosis of relapsing or progressive MS * Education of at least Grade 12 or GED * Fluent in English * Subjective cognitive and memory challenges * Internet access * Telephone access Inclusion Criteria - Caregiver Participant * 20 years + * Fluent in English * Caregiver to a MS Participant * Participant MS has given permission to Caregiver to enroll with them * Internet access * Telephone access Exclusion Criteria: * Exclusion Criteria MS Participant * Current diagnosed psychiatric disorders (e.g., schizophrenia, bipolar disorder or substance use disorder). * Other neurological disorder such as epilepsy, brain tumor, severe brain injury or mild to moderate brain injury with a history of 30 or more minutes' loss of consciousness, or other disorder that would confound the focus on MS * Diagnosed developmental attention, learning, or intellectual disorder; sensory, motor, or physical disability that would prevent engagement with the intervention or render the person unable complete study outcome measures * Exacerbation of MS symptoms (relapse) or ongoing steroid treatment within three months of study enrollment * Significant visual impairment precluding reading or writing * Lack of access to the technical resources (e.g., internet access, telephone) required for participation Exclusion Criteria - Caregiver Participant * Significant visual impairment precluding reading or writing * No reliable telephone or internet access
Contact & Investigator
Elaine T Kiriakopoulos
PRINCIPAL INVESTIGATOR
Dartmouth-Health/Dartmouth-Hitchcock, Dartmouth College
Frequently Asked Questions
Who can join the NCT06951919 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, up to 75 Years, studying Multiple Sclerosis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06951919 currently recruiting?
Yes, NCT06951919 is actively recruiting participants. Contact the research team at HOBSCOTCH-MS.Research@Hitchcock.org for enrollment information.
Where is the NCT06951919 trial being conducted?
This trial is being conducted at Lebanon, United States.
Who is sponsoring the NCT06951919 clinical trial?
NCT06951919 is sponsored by Dartmouth-Hitchcock Medical Center. The principal investigator is Elaine T Kiriakopoulos at Dartmouth-Health/Dartmouth-Hitchcock, Dartmouth College. The trial plans to enroll 125 participants.
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