NCT05828030 HFNC Compared With Facial Mask in Patients With Chest Trauma Patients
| NCT ID | NCT05828030 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Taiwan University Hospital |
| Condition | Chest Trauma |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2023-04-26 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 100 participants in total. It began in 2023-04-26 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Guidelines for noninvasive ventilation (NIV) recommend continuous positive airway pressure in patients with thoracic trauma who remain hypoxic . However, no any suggestion was applied for high flow nasal cannula (HFNC). Therefore, Our aim was to determine whether HFNC reduces intubation in severe trauma-related hypoxemia.
Eligibility Criteria
Inclusion Criteria: Patients who have the following condition within 72 hours of chest trauma despite receiving standard nasal cannula oxygen therapy \[≥10 L/min\], are eligible for inclusion. * severe hypoxemic respiratory failure \[Arterial partial pressure of oxygen (PaO2)/fraction of inspired oxygen fraction(FiO2) \<300 mmHg\] * with a respiratory rate \>25 breaths/minute and difficulty breathing, or respiratory distress * PaCO2 of 45 mmHg or higher (if the patient requires emergency surgery with endotracheal intubation and mechanical ventilation, the time of inclusion will be the start of the post-extubation period. (Note: For patients who receive emergency trauma surgery with endotracheal intubation and mechanical ventilation, the time of inclusion assessment will be 72 hours after extubation.) Exclusion Criteria: 1. Patients with a Glasgow Coma Scale less than 8 or severe brain injury. 2. Patients with any contraindications to non-invasive ventilation, including acute gastrointestinal bleeding, upper airway obstruction, or hemodynamic instability. 3. Facial trauma involving skull base fractures, facial bone fractures, or orbital floor fractures. 4. Severe injuries involving the nasal sinuses. 5. Patients with cervical spine injuries. 6. Patients with increased intracranial pressure. 7. Patients with facial, nasal, or airway structural abnormalities or surgery that prevents the use of appropriate nasal cannula. 8. Patients after upper airway surgery. 9. Patients who are unable to clearly express their willingness to sign informed consent.
Contact & Investigator
Hsien-Chi Liao, MD
PRINCIPAL INVESTIGATOR
department of trauma of National University Hospital
Frequently Asked Questions
Who can join the NCT05828030 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, up to 99 Years, studying Chest Trauma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05828030 currently recruiting?
Yes, NCT05828030 is actively recruiting participants. Contact the research team at polarisliao@hotmail.com for enrollment information.
Where is the NCT05828030 trial being conducted?
This trial is being conducted at Taipei, Taiwan, Taipei, Taiwan.
Who is sponsoring the NCT05828030 clinical trial?
NCT05828030 is sponsored by National Taiwan University Hospital. The principal investigator is Hsien-Chi Liao, MD at department of trauma of National University Hospital. The trial plans to enroll 100 participants.