NCT06637657 Guided Optimisation of Long-term Disease rEduction in secoNdary Prevention of CVD
| NCT ID | NCT06637657 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
| Condition | Acute Coronary Syndrome |
| Study Type | OBSERVATIONAL |
| Enrollment | 5,586 participants |
| Start Date | 2024-07-09 |
| Primary Completion | 2029-01 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
The goal of this observational study is to evaluate the implementation of a 'first-time-right' pharmacological treatment strategy in patients hospitalized with coronary artery disease. The main question it aims to answer is: Does early (immediately post-event) initiation of a full set of guideline-based, individualized, preventive medication lead to reductions in cardiovascular events compared to current practice (incremental titration strategies)? Researchers will compare the 'first-time-right' strategy group to the current practice group to see if there are improvements in major adverse cardiac and cerebrovascular events (MACE) at 36 months. Participants will: * Receive either the 'first-time-right' strategy or current practice for secondary prevention. * Be monitored (data collection) through routine clinical visits at baseline, 8 weeks, 12, and additional telephone contacts at 24, and 36 months after discharge. * Complete online questionnaires at hospitalization, 8 weeks, 12, 24, and 36 months after discharge.
Eligibility Criteria
Inclusion Criteria: * \>18 years of age (no upper limit) * Coronary event, i.e. ACS or coronary revascularisation * Able to provide informed consent Exclusion Criteria: * (short-term planned) pregnancy or breast feeding * Dialysis