NCT06800430 Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery
| NCT ID | NCT06800430 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Edinburgh |
| Condition | Coronary Artery Bypass |
| Study Type | OBSERVATIONAL |
| Enrollment | 70 participants |
| Start Date | 2025-03-28 |
| Primary Completion | 2027-03-28 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 70 participants in total. It began in 2025-03-28 with a primary completion date of 2027-03-28.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Coronary artery bypass graft (CABG) surgery is the commonest type of heart operation performed. During this, arteries or veins (termed 'grafts') are used to supply blood around blockages within the blood vessels that supply the heart. Unfortunately, these grafts can sometimes fail, and patients can also experience complications like heart attacks and strokes, after surgery. It is known that vein grafts are more likely to narrow over time. Additionally, treating vein graft failure is very challenging, as repeat surgery is riskier and procedures to stent open the veins can also fail. However, it is not fully understood why these complications occur. In this study, the investigators will use an imaging technique called a total-body Positron Emission Tomography (PET) scan. This uses special radioactive dyes (radiotracers) to look at what is happening inside vein grafts. With this technique, the investigators will also be able to see what is happening to the heart, brain and wider parts of the body after CABG surgery. This study will aim to recruit 70 participants in total (maximum 150). 40 (maximum of 120) of these participants will have recently undergone CABG surgery and received ≥1 vein graft. The remaining 30 will have undergone CABG surgery ≥5 years ago and will have symptoms suggestive of vein graft failure. The study will last a total of 36 months and will involve participants undertaking the following assessments: 1. Total-body Positron Emission Tomography and Computed Tomography (PET-CT) scan 2. Ultrasound scan of the heart (echocardiogram) 3. A blood test - up to four tablespoons (60 mL) of blood will be taken for immediate testing and the remainder will be stored for future ethically approved studies.
Eligibility Criteria
INCLUSION CRITERIA: Cohort 1: Patients undergoing CABG surgery * Males and females over 18 years of age * Patients undergoing CABG surgery for multivessel coronary artery disease, who receive at least one saphenous vein graft Cohort 2: Patients with symptomatic saphenous vein graft vasculopathy * Males and females over 18 years of age * Patients who underwent CABG surgery ≥ 5 years prior to recruitment for multivessel disease and received 2 or more saphenous vein grafts * Referred for invasive coronary angiography due to recurrent symptoms and with a high suspicion of graft vasculopathy EXCLUSION CRITERIA: * Patients with a life expectancy of \< 2 years * Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2) * Patients on immunosuppressive therapies * Females of child-bearing age who are pregnant or breastfeeding, * Known allergy or contraindications to iodinated contrast or radiotracer * Patients who are unable to tolerate the supine position * Patients who are unable to provide informed consent
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06800430 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Coronary Artery Bypass. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06800430 currently recruiting?
Yes, NCT06800430 is actively recruiting participants. Contact the research team at lclark15@ed.ac.uk for enrollment information.
Where is the NCT06800430 trial being conducted?
This trial is being conducted at Edinburgh, United Kingdom.
Who is sponsoring the NCT06800430 clinical trial?
NCT06800430 is sponsored by University of Edinburgh. The trial plans to enroll 70 participants.