NCT07480590 GLOW: Gender-Affirming Care and Mental Health: A Longitudinal Study On Quality of Life, Work Life, and Healthcare Outcomes
| NCT ID | NCT07480590 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Region Skane |
| Condition | Gender Dysphoria, Adult |
| Study Type | OBSERVATIONAL |
| Enrollment | 500 participants |
| Start Date | 2025-12-01 |
| Primary Completion | 2030-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 500 participants in total. It began in 2025-12-01 with a primary completion date of 2030-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Gender-Affirming Care and Mental Health (GLOW) investigates the psychological, medical, and social factors that influence the outcomes of gender-affirming care, as well as its impact on mental health, work capacity, and quality of life. Gender dysphoria is defined as the incongruence of a person's experienced gender and sex assigned at birth. In Sweden, the prevalence of gender dysphoria has increased significantly in recent decades. Still there is no consensus on the long-term outcomes ofgender-affirming care. 1. What are the baseline characteristics in individuals seeking gender-affirming care and do any of these predict outcomes of gender-affirmative care?2. Do individuals with gender dysphoria experience improved or reduced quality of life, gender congruence, or functional capacity after gender-affirming care?3. Does gender-affirming care reduce or increase psychiatric symptoms and self-concept clarity?4. What are the effects of gender-affirming care on mortality, work capacity, and healthcare resource utilization as compared to an age and gender matched control group?Data and MethodGLOW targets patients at the Gender Dysphoria Clinic, Region Skåne a National Highly Specialized Care unit (NHV). Mixed methods will be used to analyze data from national registries and self-reported assessments.The NHV status ensures standardized high-quality data collection and clinical follow-up, making this project a unique opportunity to evaluate the care given to individuals with gender dysphoria.Societal Relevance and Utility The growing demand for gender-affirming care underscores the need for research to identify the most effective interventions. The results may also help reduce stigma and improve social integration for individuals with genderdysphoria.GLOW is a longitudinal mixed-methods study based at the NHV Gender Dysphoria Clinic in Region Skåne. It includes registry-based, qualitative interviews and repeated self-report measures up to 5 years after baseline assessment. Quantitative analyses will include regression models and Bayesian methods.
Eligibility Criteria
Inclusion Criteria: * All adults (18+) referred to the NHV clinic for gender dysphoria assessment in Region Skåne. Exclusion Criteria: * Inability to read/write Swedish * Protected identity status
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07480590 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Gender Dysphoria, Adult. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07480590 currently recruiting?
Yes, NCT07480590 is actively recruiting participants. Contact the research team at emma.claesdotter-knutsson@regionskane.se for enrollment information.
Where is the NCT07480590 trial being conducted?
This trial is being conducted at Malmö, Sweden.
Who is sponsoring the NCT07480590 clinical trial?
NCT07480590 is sponsored by Region Skane. The trial plans to enroll 500 participants.