NCT04012905 Giant Cell Arteritis: Comparison Between Two Standardized Corticosteroids Tapering
| NCT ID | NCT04012905 |
| Status | Recruiting |
| Phase | Phase 3 |
| Sponsor | University Hospital, Caen |
| Condition | Giant Cell Arteritis |
| Study Type | INTERVENTIONAL |
| Enrollment | 150 participants |
| Start Date | 2021-03-03 |
| Primary Completion | 2028-05-03 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 3 trials are large pivotal studies comparing the treatment to current standard of care or placebo. Your participation directly contributes to the evidence needed for regulatory approval.
This trial targets 150 participants in total. It began in 2021-03-03 with a primary completion date of 2028-05-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Corticosteroid therapy has always been the standard treatment for giant cell arteritis (GCA), with very good initial clinical efficacy but a high relapse rate when it declines. The target population of this condition, often elderly, is particularly exposed to the numerous undesirable effects of corticosteroid therapy, and this especially as its duration lengthens with the re-increases of doses according to relapses: metabolic complications, osteo-muscular , infectious or neuropsychiatric. Investigators propose to compare prospectively the results of a "conventional" corticosteroid regimen as recommended by European societies, to those of a "lighter and / or shorter" scheme, inspired by recent North American trials. , including the largest prospective global study in the field. Investigators hypothesize non-inferiority of the lightened regimen for relapse rate without relapse at S52, but with a decrease in treatment-related adverse events whose cumulative doses should be lower. Investigators therefore plan to include prospectively over 3 years 150 patients, 75 for each of the two arms, with a newly diagnosed ACG. A randomization of the treatment arm will be performed and a predefined pattern of cortisone adapted to body weight will be given to the patient. Relapse rates, maintenance of remission, cumulative doses of cortisone and adverse effects of treatment will be analyzed at the 52nd week of the introduction of corticosteroid therapy. An interim analysis is planned at S28.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 50 years * Patient with temporal arteritis giant cell match 2 of the 4 criteria of the American College of Rheumatology (ACR) that given : * a temporal artery biopsy compatible with a diagnosis of CAG or * an abdominal thoracic aortitis diagnosed by Angio CT, MR angiography or PET scanner or * Echo Doppler compatible with a diagnosis of CAG * Oral corticosteroid treatment started up to 14 days, the initial dose is less or equal to 1 mg / Kg * Patient wo has given its written consent Patient affiliated with a social security Exclusion Criteria: Subjects checking one of the criteria for non-inclusion may be eligible to participate in the research. These criteria may include: * Early treatment of CAG disease with a dose\> 1 mg / kg whatever the duration * Corticosteroids already started over 14 days * Giant arteritis cell on relapse * dementia syndrome * No compliant patient * Patients who live more than 150 km from the investigation center * Person under judicial protection, guardianship * Hypersensitivity to prednisone or any of its excipients * Infection requiring an systemic treatment * Evolutive viroses (Hepatitis, Herpes, varicella-zoster virus) * Immunization with live vaccines / mitigated during the 8 weeks preceding inclusion * Pregnancy, breastfeeding women or women of childbearing potential not using contraception
Contact & Investigator
Hubert De BOYSSON, MD
PRINCIPAL INVESTIGATOR
University Hospital, Caen
Frequently Asked Questions
Who can join the NCT04012905 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, studying Giant Cell Arteritis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT04012905 trial and what does that mean for participants?
Phase 3 trials are large-scale studies comparing the new treatment to existing standards of care or a placebo. They provide the evidence needed for regulatory approval. This trial targets 150 participants.
Is NCT04012905 currently recruiting?
Yes, NCT04012905 is actively recruiting participants. Contact the research team at deboysson-h@chu-caen.fr for enrollment information.
Where is the NCT04012905 trial being conducted?
This trial is being conducted at Caen, France.
Who is sponsoring the NCT04012905 clinical trial?
NCT04012905 is sponsored by University Hospital, Caen. The principal investigator is Hubert De BOYSSON, MD at University Hospital, Caen. The trial plans to enroll 150 participants.