NCT03716908 Genotype-phenotype Correlation Study of Presymptomatic and Symptomatic DFNA9 Patients
| NCT ID | NCT03716908 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Jessa Hospital |
| Condition | Vestibular Diseases |
| Study Type | OBSERVATIONAL |
| Enrollment | 70 participants |
| Start Date | 2018-06-01 |
| Primary Completion | 2020-02-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 70 participants in total. It began in 2018-06-01 with a primary completion date of 2020-02-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
DFNA9 (Deafness Autosomal Dominant 9) is an autosomal dominant hereditary hearing loss which is associated with vestibular deterioration. The most recent genotype-phenotype correlation studies have been conducted more than 15 years ago. Meanwhile, emerging and valuable vestibular tests have been added to the vestibular test battery. These tests were not available at the time of the correlation studies. The aim of this study is to carry out a prospective cross-sectional study on symptomatic and presymptomatic affected carriers of the Pro51Ser (P51S) Coagulation Factor C Homology (COCH) mutation in order to correlate vestibular data using the complete vestibular test battery with the known data on hearing and vestibular function in relation to age.
Eligibility Criteria
Inclusion Criteria: * subject must be 18 year of older * subject is a family member of the family pedigree's proband(s) carrying a P51S COCH mutation Exclusion Criteria: * subject is younger than 18 years * subject is not a family member of the pedigree's proband(s) carrying a P51S * subject cannot undergo investigations (medical and/or mental reasons) * subject is not willing to be enrolled into the study * subject suffers other concomitant middle or inner ear disease * subject has undergone middle ear or inner ear surgery * subject suffers other concomitant vestibular disease than DFNA9 * subject has undergone vestibular surgery or other non-invasive vestibular treatment (gentamicin intratympanal injections for example)
Contact & Investigator
Frequently Asked Questions
Who can join the NCT03716908 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Vestibular Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT03716908 currently recruiting?
Yes, NCT03716908 is actively recruiting participants. Contact the research team at sebastien.janssensdevarebeke@jessazh.be for enrollment information.
Where is the NCT03716908 trial being conducted?
This trial is being conducted at Antwerp, Belgium.
Who is sponsoring the NCT03716908 clinical trial?
NCT03716908 is sponsored by Jessa Hospital. The trial plans to enroll 70 participants.