NCT04772963 Genetics of Central Nervous System Arteriovenous Malformations (GENE-MAV)
| NCT ID | NCT04772963 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild |
| Condition | Arteriovenous Malformations |
| Study Type | OBSERVATIONAL |
| Enrollment | 300 participants |
| Start Date | 2022-02-17 |
| Primary Completion | 2026-03 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
Cerebral and medullary arteriovenous malformations (AVMs) lead to arterial and venous networks to communicate pathologically, creating an arteriovenous shunt. The occurrence of intracranial haemorrhage is the most important prognostic factor of AVMs because it is associated with a significant morbidity and mortality. The genetic, molecular and cellular mechanisms that cause vascular malformations of the central nervous system are partially known and the influence of genetic damage on the prognosis of AVMs is poorly known.
Eligibility Criteria
Inclusion Criteria: * Patient with a vascular malformation of the cerebral or medullary identified on diagnostic imaging (angio-CT, angio-MRI or diagnostic angiography) for which clinical monitoring alone or intervention (endovascular treatment, surgery or radiosurgery) is planned in the centres participating in the research. Exclusion Criteria: * Pregnant, parturient or breastfeeding woman