| NCT ID | NCT03357536 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Institut Pasteur |
| Condition | Listeriosis |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2017-11-28 |
| Primary Completion | 2027-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 100 participants in total. It began in 2017-11-28 with a primary completion date of 2027-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Listeriosis is a rare, severe foodborne infection, responsible for severe invasive infections. It occurs in the great majority of cases in elderly patients and / or patients with comorbidities, with a deficit of innate or cellular immunity. Pregnancy is also a risk factor. The Multicentric Observational NAtional Analysis of Listeriosis and Listeria (MONALISA) is an ongoing national case-control prospective study on listeriosis implemented since 2009 to study risk and prognosis factors for listeriosis. In this cohort, which enrolled 902 patients on 1 August 2014, 7% of patients with neurolisteriosis are under 40 years of age and have no identified risk factor. Genetic susceptibility is suspected in these patients. Genetic susceptibility could also explain the inconstant development of a neurolisteriosis or fetal infection, as well as the particular severity of some infections (death, foetal loss, neurological sequelae). The aim of the study is to identify genetic susceptibility to Listeriosis.
Eligibility Criteria
Inclusion Criteria for patients with Listeriosis : * Microbiologically documented Listeriosis (either a severe form of listeriosis, or an atypical form of listeriosis, or less than 40 years old and without any co-morbidity identified) * Affiliated or beneficiary of a social security system * Informed and written consent Inclusion Criteria for volunteers related to patients with Listeriosis (after identifying a genetic susceptibility in the patient with Listeriosis) : * defined as father, mother, brother (s), sister (s), child (ren), grandparent (s), uncle (s), aunt (s), cousin (s), nephew (s), niece (s). * Affiliated or beneficiary of a social security system * Informed and written consent Exclusion Criteria for volunteers related to patients with Listeriosis: * Inability to consent
Contact & Investigator
Marc Lecuit
STUDY DIRECTOR
Institut Pasteur
Frequently Asked Questions
Who can join the NCT03357536 clinical trial?
This trial is open to participants of all sexes, studying Listeriosis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT03357536 currently recruiting?
Yes, NCT03357536 is actively recruiting participants. Contact the research team at marc.lecuit@pasteur.fr for enrollment information.
Where is the NCT03357536 trial being conducted?
This trial is being conducted at Paris, France.
Who is sponsoring the NCT03357536 clinical trial?
NCT03357536 is sponsored by Institut Pasteur. The principal investigator is Marc Lecuit at Institut Pasteur. The trial plans to enroll 100 participants.