NCT03932162 Gene Expression Changes In Young and Geriatric Skin
| NCT ID | NCT03932162 |
| Status | Recruiting |
| Phase | EARLY_Phase 1 |
| Sponsor | Wright State University |
| Condition | UVB Phototherapy Burn |
| Study Type | INTERVENTIONAL |
| Enrollment | 24 participants |
| Start Date | 2019-09-06 |
| Primary Completion | 2025-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 24 participants in total. It began in 2019-09-06 with a primary completion date of 2025-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.
Eligibility Criteria
Inclusion Criteria: * Male/Female * White skin (Fitzpatrick types I and II) * Age 21-30 or 65 and older * Able to comprehend procedures/risks Exclusion Criteria: * Known photosensitivity * Currently on photosensitizing medications * Diabetes Mellitus * History of abnormal scarring * History of skin infections * Known allergy to lidocaine local anesthetic * Pregnancy or nursing * Other serious health issues
Contact & Investigator
Jeffrey B Travers, MD, PhD
PRINCIPAL INVESTIGATOR
Wright State University
Frequently Asked Questions
Who can join the NCT03932162 clinical trial?
This trial is open to participants of all sexes, aged 21 Years or older, studying UVB Phototherapy Burn. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT03932162 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT03932162 currently recruiting?
Yes, NCT03932162 is actively recruiting participants. Contact the research team at pturesearch@wrightstatephysicians.org for enrollment information.
Where is the NCT03932162 trial being conducted?
This trial is being conducted at Fairborn, United States.
Who is sponsoring the NCT03932162 clinical trial?
NCT03932162 is sponsored by Wright State University. The principal investigator is Jeffrey B Travers, MD, PhD at Wright State University. The trial plans to enroll 24 participants.