Fully Automated High-Throughput Quantitative MRI of the Liver
Trial Parameters
Brief Summary
The purpose of this research is to see if a new automated magnetic resonance imaging (MRI) method will be able to improve the images taken of the liver. Participants will have either known or suspected liver disease, known or suspected iron overload syndrome, or be a healthy adult. Participants will be in the research study for one day.
Eligibility Criteria
Eligibility Criteria for Substudies 1, 2, 4, 5 Inclusion Criteria: * Age 18 years or older Exclusion Criteria: * Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc) * Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening) Eligibility Criteria for Substudy 3 Inclusion Criteria: * Age 7 years or older * One of: * Known or suspected liver iron overload * Known or suspected elevated liver fat Exclusion Criteria: * Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc) * Patients requiring intravenous (IV) conscious sedation for imaging are not eligible; patients requiring mild, oral anxiolytics for the MRI will be allowed to participate as long as the following criteria are met: * The subject has their own prescription for the medication. * The informed consent process is conducted prior to the self-administration of this medication *