NCT06557525 Focused Research On Neurofeedback Therapy In Eradicating Depression (FRONTIER)

Trial Parameters

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Brief Summary

This is an exploratory study to test the efficacy of a novel EEG neurofeedback method in depressed patients. The investigators will measure the change in depressive symptoms before and after the intervention of the novel EEG neurofeedback method using the Depression Rating Scale (primary endpoint). In addition, The investigators will measure the changes in brain activity before and after the intervention using fMRI, and compare the changes in depressive symptoms over the treatment period (secondary endpoint).

Eligibility Criteria

Inclusion Criteria: * 1\. Adults (at least 18 years old at the time consent is obtained) * 2\. Major depressive episode as defined by the diagnostic criteria of the DSM 5 * 3\. One of the following 1. Hamilton Depression Rating Score (HDRS 17) of 19 or higher 2. Montgomery Asberg Depression Rating Scale score of 20 or higher 3. Any other patient deemed appropriate by the PI (subprincipal investigator) * 4\. With respect to taking antidepressants, any of the following 1. not taking antidepressants 2. If taking antidepressants, willingness to continue them for the duration of the program. * 5\. If receiving psychotherapy, agree to continue the same psychotherapy for the duration of study participation * 6\. Have treated by a psychiatrist * 7\. Written informed consent * 8\. No planned change in employment status after the study begins Exclusion Criteria: * 1\. High risk of suicide, such as suicidal ideation or suicide attempts * 2\. History of hospitalization for depression or suicidal b

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