NCT06772038 Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion
| NCT ID | NCT06772038 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Bicetre Hospital |
| Condition | Hemodynamic |
| Study Type | OBSERVATIONAL |
| Enrollment | 64 participants |
| Start Date | 2025-01-05 |
| Primary Completion | 2025-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 64 participants in total. It began in 2025-01-05 with a primary completion date of 2025-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Fluid responsiveness is a critical determinant guiding fluid therapy in critically ill patients. However, excessive fluid administration can result in fluid overload, leading to venous congestion and worse clinical outcomes. Venous congestion, a marker of impaired fluid clearance, is increasingly recognized as a significant contributor to poor prognosis. Previous studies have demonstrated the coexistence of fluid responsiveness and venous congestion in critically ill patients. Notably, these studies were limited by the absence of fluid challenge-the gold standard for assessing fluid responsiveness-leaving the dynamic relationship between fluid responsiveness and venous congestion incompletely understood. This study aims to investigate the interplay and temporal evolution of fluid responsiveness and venous congestion following a standardized fluid challenge in critically ill patients.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years * Hospitalized in the intensive care unit (ICU) * Hemodynamic monitoring in place, with a pulse wave contour analysis- derived estimation of cardiac output (either calibrated or uncalibrated) * Decision made by clinicians to perform volume expansion through intravenous infusion of crystalloid fluid Exclusion Criteria: * Pregnancy * Refusal to participate by relatives of the patient or the patient himself
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06772038 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 99 Years, studying Hemodynamic. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06772038 currently recruiting?
Yes, NCT06772038 is actively recruiting participants. Contact the research team at sixiang@mail.sysu.edu.cn for enrollment information.
Where is the NCT06772038 trial being conducted?
This trial is being conducted at Guangzhou, China, Shenzhen, China, Paris, France.
Who is sponsoring the NCT06772038 clinical trial?
NCT06772038 is sponsored by Bicetre Hospital. The trial plans to enroll 64 participants.