Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia
Trial Parameters
Brief Summary
Hereditary Spastic Paraplegia (HSP) is a diverse group of genetic neurological conditions causing progressive weakness and spasticity in the lower limbs, severely reducing balance and gait capabilities. There is currently a lack of structured neurorehabilitation programs aimed at improving gait in adults with HSP. This protocol seeks to assess the feasibility and effectiveness of a structured training approach focusing on flexibility, muscle strength, motor control, balance, and aerobic capacity. To this end, twenty adults diagnosed with HSP will engage in 10 to 16 sessions, each lasting 60 to 120 minutes, guided by a therapist once or twice a week, depending on individual preferences. At the end of the program, participants will receive a transfer package, including written instructions (a manual) and video tutorials, to encourage ongoing exercise at home. Assessments will occur before the intervention (T0), immediately after (T1), and three months later (T2). The primary outcomes will measure the feasibility of the program, including recruitment, retention, adherence, the absence of adverse events, and patient satisfaction. Secondary outcomes will focus on improvements in gait capabilities such as gait endurance and gait speed.
Eligibility Criteria
Inclusion Criteria: * Adults diagnosed with Hereditary Spastic Paraplegia. * Presence of any functional deficit in the lower limbs that affects walking, such as muscle weakness, hypertonia, or balance issues. * Ability to walk without the need for physical contact with another person, as defined by a Functional Ambulation Category score of 3 or higher. * Ability to understand simple instructions, comprehend the purpose of the study, willingness to participate and undergo at least 10 treatment sessions, eligible and willing to sign the informed consent. Exclusion Criteria: * Botulinum toxin or surgery to treat lower limb hypertonia in the six months prior to enrollment in the study. * Contraindications for moderate physical activity, such as stretching exercises, muscle strength training, and aerobic capacity training.