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Recruiting NCT06991595

Fertility Limiting Diseases of Pelvic Organs and Their Influence on Receptivity of Endometrial Cavity: Prospective Clinical Trial

Trial Parameters

Condition Adenomyosis
Sponsor Charles University, Czech Republic
Study Type OBSERVATIONAL
Phase N/A
Enrollment 236
Sex FEMALE
Min Age 18 Years
Max Age 45 Years
Start Date 2023-04-01
Completion 2026-04-01
Interventions
cytoreductive resection of adenomyosis, myomectomy, resection of endometriosishysteroscopy

Brief Summary

In this project, we will characterize the effects of fertility limiting diseases of pelvic organs on the receptivity of the endometrium. The primary aim of the project is the characterization of endometrium in patients with infertility suffering from AD, UF and DE, and compare it with infertile patients with minimal or mild endometriosis but no AD or UF (ETRS group), and with healthy women with only male factor of infertility (CTRL group, controls). The proper infertility treatment of patients with AD,UF and endometriosis is controversial and lacking clear evidence based algorithms. Despite their topical character, especially AD and DE (and UFs as well if present as multiple lesions) can be classified as systemic diseases in relation to women´s fertility. The presumed impact of these pathologies to endometrial receptivity (no matter they do not occur in the uterine cavity itself) can beseen as a fascinating hypothesis. Eradication of these diseases could have a potential to increase the prognosis of these women fundamentally.

Eligibility Criteria

Inclusion Criteria: * agreement with participation in the study * age between 18 - 45 years (at the start of patient´s participation in the study)women with at least 1 year infertility Exclusion Criteria: \-

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