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Recruiting NCT05677607
Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease
Trial Parameters
Condition ICAS - Intracranial Atherosclerosis
Sponsor Chinese PLA General Hospital
Study Type OBSERVATIONAL
Phase N/A
Enrollment 300
Sex ALL
Min Age 30 Years
Max Age N/A
Start Date 2023-01-01
Completion 2027-12-31
Interventions
Magnetic resonance imaging
Brief Summary
The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing biomarkers for the early prevention and treatment of cerebrovascular disease.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years * At least one intracranial artery ≥ 50% atherosclerotic stenosis * Modified Rankin Scale \< 2 * Mini-mental State Examination \> 24 Exclusion Criteria: * Concurrent ipsilateral extracranial artery ≥ 50% stenosis * Pregnant women * Contraindications to magnetic resonance examination (patients with pacemakers, nerve stimulators, artificial metal heart valves and other metal foreign bodies)