Fecal Transplantation to Eradicate Colonizing Emergent Superbugs
Trial Parameters
Brief Summary
Carriage of multi-drug and extensive-drug resistant Gram negative bacteria (MDR-GNB) is associated with an increased risk of infections by these bacteria for the carriers and a high risk of dissemination both in the healthcare setting and the community; the main MDR-GNB reservoir is the fecal microbiota. To prevent both infections and dissemination, effective measures to decolonize subjects carrying MDR-GNB are urgently needed. Animal models, case reports and cohort studies suggest fecal microbiota transplantation (FMT) may be efficient for MDR-GNB decolonization.
Eligibility Criteria
Inclusion Criteria: Inclusion Criteria for patients: * ≥ 18 years and \< 105 years * Patient with at least one positive rectal swab for enterobacteria: extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) or carbapenem-resistant Enterobacteriaceae (CRE), or who have had an ESBL-E or CRE infection within the year For ESBL-E carriers: an ESBL-E infection within the year is mandatory \- Patient able to take 50 capsules orally in a day and without swallowing disorders Inclusion Criteria for healthy volunteers donors: * Healthy subjects ≥ 18 years and \< 50 years * Body mass index \< 30 kg/m\^2 * Regular bowel movement defined as at least 1 stool every 2 daysand maximum than 3 stools per day Exclusion Criteria: Exclusion Criteria for patients: * Current antibiotic treatment with te exception of long term antibiotic prophylaxis (duration of at least 3 months/year) * Patients hospitalized in the intensive care unit * Pregnancy or breastfeeding during the study * Women of childb