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Recruiting NCT06442930

NCT06442930 EXtubation Related Complications - the EXTUBE Study (EXTUBE)

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Clinical Trial Summary
NCT ID NCT06442930
Status Recruiting
Phase
Sponsor University Health Network, Toronto
Condition Extubation
Study Type OBSERVATIONAL
Enrollment 3,000 participants
Start Date 2025-04-14
Primary Completion 2027-12

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age N/A
Study Type OBSERVATIONAL

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 3,000 participants in total. It began in 2025-04-14 with a primary completion date of 2027-12.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

EXTUBE is an international, multicentre, prospective cohort study evaluating the incidence, risk factors, and outcomes of extubation-related complications and describing clinical practices related to extubation after general anesthesia or after critical illness in the operating room (OR), out of OR anesthesia location or intensive care unit (ICU).

Eligibility Criteria

Inclusion Criteria: * Adult patients (≥18 years old) * Undergoing extubation of an endotracheal tube (including index extubation and re-extubations) after general anesthesia in the OR, out of OR anesthesia location or ICU * Undergoing extubation during the specified enrollment window Exclusion Criteria: * Patients will be excluded if the extubation is performed in the context of withdrawal of life support measures, * Patients will be excluded if the extubation is performed for tracheostomy decannulation For each patient who is not included, reasons for exclusion will be reported.

Contact & Investigator

Central Contact

Matteo Parotto, MD, PhD

✉ matteo.parotto@uhn.ca

📞 +1 416 340 3567

Principal Investigator

Matteo Parotto, MD, PhD

PRINCIPAL INVESTIGATOR

UHN

Frequently Asked Questions

Who can join the NCT06442930 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, studying Extubation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT06442930 currently recruiting?

Yes, NCT06442930 is actively recruiting participants. Contact the research team at matteo.parotto@uhn.ca for enrollment information.

Where is the NCT06442930 trial being conducted?

This trial is being conducted at Tucson, United States, Little Rock, United States, Gainesville, United States, Chicago, United States and 11 additional locations.

Who is sponsoring the NCT06442930 clinical trial?

NCT06442930 is sponsored by University Health Network, Toronto. The principal investigator is Matteo Parotto, MD, PhD at UHN. The trial plans to enroll 3,000 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology