Explosive Synchronization of Brain Network Activity in Chronic Pain
Trial Parameters
Brief Summary
This project is being conducted to evaluate the impact of explosive synchronization (ES) and its treatment with non-invasive brain stimulation in fibromyalgia (FM). The study design has three components, however, only 2 aims are enrolling participants. The first part (Aim1) is a cross sectional assessment of brain network explosive synchronization activity, connectivity, and response to pain in healthy controls and age and sex-matched fibromyalgia patients; the third part (Aim 3) is a longitudinal assessment of fibromyalgia patients undergoing one week of sham followed by high-definition transcranial direct current stimulation (HD-tDCS) of the motor cortex (M1) or one week of ES HD-tDCS of a brain region identified from computer modelling (Aim 2).
Eligibility Criteria
Inclusion Criteria For Fibromyalgia Participants: * Satisfy the American College of Rheumatology (2011) survey criteria for the classification of Fibromyalgia (FM). * Continued presence of pain for more than 50% of days for the past month. * Mean recalled pain over the last seven days (7-day recall) greater than or equal to 3 on a 10 centimeter (cm) Visual Analog Scale (VAS) for pain; 7-day recall * Willing to limit the introduction of any new medications or treatment modalities for control of FM symptoms during the study. * Right-handed. * Able to travel to the study site to receive (HD-tDCS) treatments five times weekly * Understanding and willing to complete all study procedures. * Capable of giving written informed consent. Inclusion Criteria for Healthy Control Participants: * Right-handed * Pain less than 0.5cm on a 10cm Visual Analog Scale (VAS) for pain; 7-day recall * Understanding and willing to complete all study procedures * Capable of giving written informed consent Exclus